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    NOTCH3 notch receptor 3 [ Bos taurus (cattle) ]

    Gene ID: 789485, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NOTCH3provided by VGNC
    Official Full Name
    notch receptor 3provided by VGNC
    Primary source
    VGNC:VGNC:32178
    See related
    Ensembl:ENSBTAG00000043971
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NOTCH3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (7910617..7950466)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene epoxide hydrolase 3 Neighboring gene AFG3-like protein 1 Neighboring gene olfactory receptor family 10 subfamily B member 1, pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway. Boras E, et al. Cytokine, 2014 Oct. PMID 24972386

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Monomeric CRP combined with Notch-3 activator promote angiogenesis through the PI3K/Akt pathway.
      Title: Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenic locus notch homolog protein 3
    Names
    notch 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7910617..7950466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003586246.4 → XP_003586294.1  neurogenic locus notch homolog protein 3

      UniProtKB/TrEMBL
      E1BPT8
      Related
      ENSBTAP00000053357.2, ENSBTAT00000060960.4
      Conserved Domains (12) summary
      smart00004
      Location:1390 → 1427
      NL; Domain found in Notch and Lin-12
      smart00179
      Location:658 → 687
      EGF_CA; Calcium-binding EGF-like domain
      COG0666
      Location:1787 → 1903
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:159 → 196
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:1876 → 2002
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:1435 → 1469
      Notch; LNR domain
      pfam06816
      Location:1518 → 1567
      NOD; NOTCH protein
      pfam07684
      Location:1588 → 1647
      NODP; NOTCH protein
      pfam11936
      Location:2222 → 2284
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1920 → 2012
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:1868 → 1923
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:1915 → 1946
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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