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    ZNF200 zinc finger protein 200 [ Homo sapiens (human) ]

    Gene ID: 7752, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF200provided by HGNC
    Official Full Name
    zinc finger protein 200provided by HGNC
    Primary source
    HGNC:HGNC:12993
    See related
    Ensembl:ENSG00000010539 MIM:603231; AllianceGenome:HGNC:12993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 8.8), appendix (RPKM 2.8) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF200 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3222325..3235158, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3249433..3263296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3272325..3285158, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily F member 1 Neighboring gene tRNA-Lys (anticodon CTT) 14-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3261768-3261996 Neighboring gene olfactory receptor family 1 subfamily F member 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10315 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:3293322-3294521 Neighboring gene MEFV innate immunity regulator, pyrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10318 Neighboring gene long intergenic non-protein coding RNA 921

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. Deng Z, et al. Genomics, 1998 Oct 1. PMID 9787081
    2. Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a. Nishida M, et al. Genes Cells, 2007 Jul. PMID 17584299
    3. A candidate gene for familial Mediterranean fever. French FMF Consortium. Nat Genet, 1997 Sep. PMID 9288094
    4. A transcriptional Map of the FMF region. Bernot A, et al. Genomics, 1998 Jun 1. PMID 9653642
    5. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Adams MD, et al. Nat Genet, 1993 Aug. PMID 8401585

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF200 is a novel binding partner of G9a.
      Title: Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45293

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 200

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145446.2 → NP_001138918.1  zinc finger protein 200 isoform 3

      See identical proteins and their annotated locations for NP_001138918.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at the ultimate coding exon compared to transcript variant 1. This results in an isoform (3) missing 1 aa compared to isoform 1. Variants 4,5 and 6 encode the same isoform.
      Source sequence(s)
      AA338573, BC054005, DB031650, Y14443
      Consensus CDS
      CCDS45395.1
      UniProtKB/Swiss-Prot
      P98182
      Related
      ENSP00000380080.4, ENST00000396871.8
      Conserved Domains (4) summary
      COG5048
      Location:253 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001145447.2 → NP_001138919.1  zinc finger protein 200 isoform 3

      See identical proteins and their annotated locations for NP_001138919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame acceptor splice site at the ultimate coding exon compared to transcript variant 1. This results in an isoform (3) missing 1 aa compared to isoform 1. Variants 4,5 and 6 encode the same isoform.
      Source sequence(s)
      AA338573, AK056010, BC032575
      Consensus CDS
      CCDS45395.1
      UniProtKB/Swiss-Prot
      P98182
      UniProtKB/TrEMBL
      B3KP91
      Related
      ENSP00000380079.4, ENST00000396870.8
      Conserved Domains (4) summary
      COG5048
      Location:253 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001145448.2 → NP_001138920.1  zinc finger protein 200 isoform 3

      See identical proteins and their annotated locations for NP_001138920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at the ultimate coding exon compared to transcript variant 1. This results in an isoform (3) missing 1 aa compared to isoform 1. Variants 4,5 and 6 encode the same isoform.
      Source sequence(s)
      AA338573, AK315036, DA757518, Y14443
      Consensus CDS
      CCDS45395.1
      UniProtKB/Swiss-Prot
      P98182
      Related
      ENSP00000458508.1, ENST00000575948.1
      Conserved Domains (4) summary
      COG5048
      Location:253 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain

    4. NM_003454.4 → NP_003445.2  zinc finger protein 200 isoform 1

      See identical proteins and their annotated locations for NP_003445.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AA338573, AK056010, BC032575
      Consensus CDS
      CCDS10497.1
      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1
      Related
      ENSP00000395723.3, ENST00000431561.7
      Conserved Domains (3) summary
      COG5048
      Location:254 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:266 → 291
      zf-H2C2_2; Zinc-finger double domain

    5. NM_198087.3 → NP_932353.1  zinc finger protein 200 isoform 2

      See identical proteins and their annotated locations for NP_932353.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at the penultimate coding exon compared to transcript variant 1. This results in an isoform (2) missing 1 aa compared to isoform 1.
      Source sequence(s)
      AA338573, DB031650, Y14443
      Consensus CDS
      CCDS42112.1
      UniProtKB/Swiss-Prot
      P98182
      Related
      ENSP00000380077.3, ENST00000396868.7
      Conserved Domains (4) summary
      COG5048
      Location:253 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain

    6. NM_198088.3 → NP_932354.1  zinc finger protein 200 isoform 1

      See identical proteins and their annotated locations for NP_932354.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA338573, AF060866, DA757518, Y14443
      Consensus CDS
      CCDS10497.1
      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1
      Related
      ENSP00000405786.2, ENST00000414144.7
      Conserved Domains (3) summary
      COG5048
      Location:254 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:266 → 291
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3222325..3235158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720941.3 → XP_006721004.1  zinc finger protein 200 isoform X1

      See identical proteins and their annotated locations for XP_006721004.1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1
      Conserved Domains (3) summary
      COG5048
      Location:254 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:266 → 291
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047434596.1 → XP_047290552.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    3. XM_047434599.1 → XP_047290555.1  zinc finger protein 200 isoform X2

    4. XM_047434597.1 → XP_047290553.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    5. XM_047434600.1 → XP_047290556.1  zinc finger protein 200 isoform X2

    6. XM_047434598.1 → XP_047290554.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    RNA

    1. XR_007064908.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3249433..3263296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313857.1 → XP_054169832.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    2. XM_054313867.1 → XP_054169842.1  zinc finger protein 200 isoform X2

    3. XM_054313854.1 → XP_054169829.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    4. XM_054313861.1 → XP_054169836.1  zinc finger protein 200 isoform X2

    5. XM_054313866.1 → XP_054169841.1  zinc finger protein 200 isoform X2

    6. XM_054313868.1 → XP_054169843.1  zinc finger protein 200 isoform X2

    7. XM_054313863.1 → XP_054169838.1  zinc finger protein 200 isoform X2

    8. XM_054313862.1 → XP_054169837.1  zinc finger protein 200 isoform X2

    9. XM_054313856.1 → XP_054169831.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    10. XM_054313852.1 → XP_054169827.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    11. XM_054313855.1 → XP_054169830.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    12. XM_054313860.1 → XP_054169835.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    13. XM_054313864.1 → XP_054169839.1  zinc finger protein 200 isoform X2

    14. XM_054313865.1 → XP_054169840.1  zinc finger protein 200 isoform X2

    15. XM_054313858.1 → XP_054169833.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    16. XM_054313859.1 → XP_054169834.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    17. XM_054313853.1 → XP_054169828.1  zinc finger protein 200 isoform X1

      UniProtKB/Swiss-Prot
      D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

    RNA

    1. XR_008484733.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98182.2 GenPept UniProtKB/Swiss-Prot:P98182

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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