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    DMBT1 deleted in malignant brain tumors 1 [ Sus scrofa (pig) ]

    Gene ID: 751862, updated on 20-Oct-2024

    Summary

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    Gene symbol
    DMBT1
    Gene description
    deleted in malignant brain tumors 1
    See related
    Ensembl:ENSSSCG00000055799
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in lung (RPKM 27.4), mixtures (RPKM 6.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See DMBT1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (132154346..132231274)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (43728925..43753137, complement)

    Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A1 Neighboring gene HtrA serine peptidase 1 Neighboring gene sperm associated AWN protein Neighboring gene AQN-1 protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Sperm binding to porcine oviductal cells is mediated by SRCR domains contained in DMBT1. Roldán ML, et al. J Cell Biochem, 2018 Apr. PMID 29240248
    2. Deleted in malignant brain tumor 1 is secreted in the oviduct and involved in the mechanism of fertilization in equine and porcine species. Ambruosi B, et al. Reproduction, 2013 Aug. PMID 23722152
    3. The effect of oviductal deleted in malignant brain tumor 1 over porcine sperm is mediated by a signal transduction pathway that involves pro-AKAP4 phosphorylation. Teijeiro JM, et al. Reproduction, 2012 Jun. PMID 22457434
    4. Molecular characterization of the porcine deleted in malignant brain tumors 1 gene (DMBT1). Haase B, et al. Gene, 2006 Jul 19. PMID 16624504
    5. Evolution of the spermadhesin gene family. Haase B, et al. Gene, 2005 Jun 6. PMID 15922517

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sperm binding to porcine oviductal cells is mediated by SRCR domains contained in DMBT1
      Title: Sperm binding to porcine oviductal cells is mediated by SRCR domains contained in DMBT1.
    2. Data suggest that DMBT1 is secreted by oviduct epithelium and plays role in sperm-ovum interactions during in vitro fertilization.
      Title: Deleted in malignant brain tumor 1 is secreted in the oviduct and involved in the mechanism of fertilization in equine and porcine species.
    3. Involvement of AKAP4 in the formation of the fibrous sheath on boar precursor sperm cells and the phosphorylation of pro-AKAP4 as an early step in the signal transduction pathway gated by DMBT1 that leads to sperm selection through acrosome alteration.
      Title: The effect of oviductal deleted in malignant brain tumor 1 over porcine sperm is mediated by a signal transduction pathway that involves pro-AKAP4 phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scavenger receptor cysteine-rich domain-containing protein DMBT1
    Names
    deleted in malignant brain tumors 1 protein
    hensin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

      Range
      132154346..132231274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001048188.1 → NP_001041653.1  

      UniProtKB/Swiss-Prot
      Q4A3R3
      Conserved Domains (5) summary
      smart00202
      Location:377 → 477
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:1015 → 1263
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:662 → 772
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:1056 → 1261
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:382 → 477
      SRCR; Scavenger receptor cysteine-rich domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001048188.1: Suppressed sequence

      Description
      NM_001048188.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DMBT1 (GeneID:1755).
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4A3R3.1 GenPept UniProtKB/Swiss-Prot:Q4A3R3

    Gene LinkOut

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