CORO2A coronin 2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO2Aprovided by HGNC
Official Full Name: coronin 2Aprovided by HGNC
Primary source: HGNC:HGNC:2255
See related: Ensembl:ENSG00000106789 MIM:602159; AllianceGenome:HGNC:2255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IR10; WDR2; CLIPINB
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Expression: Broad expression in small intestine (RPKM 15.5), duodenum (RPKM 14.7) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.33

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (98120975..98192637, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (110292922..110364586, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (100883257..100954919, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.
Title: Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.
The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis.
Title: Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A.
increased expression of coronin 2A is associated with the malignant phenotype of human colon carcinoma.
Title: Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling.
The candidate marker CORO2A rs1985859 and the putative marker FAM101A rs7955740 may be of value for the prediction of radiosensitivity to preoperative colorectal tumors.
Title: Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.
Observational study of gene-disease association. (HuGE Navigator)
Title: Common variants in FOXP1 are associated with generalized vitiligo.
Coronin 2A and cofilin regulate a subset of focal-adhesion-turnover events.
Title: Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.
This protein is one of 10-12 associated proteins in the purified N-CoR complex.
Title: Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

1620 (e-PCR)
- UniSTS:43016

G19641 (e-PCR)
- UniSTS:59692

RH66408 (e-PCR)
- UniSTS:16173

A001T44 (e-PCR)
- UniSTS:59693

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-144244 (e-PCR)
- UniSTS:184897

SHGC-149194 (e-PCR)
- UniSTS:173125

D15S1477 (e-PCR)
- UniSTS:474482

G35510 (e-PCR)
- UniSTS:44150

SHGC-32963 (e-PCR)
- UniSTS:421

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-2A

Names: WD protein IR10; WD repeat-containing protein 2; WD-repeat protein 2; coronin, actin binding protein, 2A; coronin-like protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003389.3 → NP_003380.3 coronin-2A

See identical proteins and their annotated locations for NP_003380.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 2. Variants 1 and 2 encode the same protein and contain the same 3' UTR.

Source sequence(s)

AK292788, AL137073, BM822208, BM976925

Consensus CDS

CCDS6735.1

UniProtKB/Swiss-Prot

Q5TBR5, Q92828, Q92829, Q9BWS5

UniProtKB/TrEMBL

A8K9S3

Related

ENSP00000343746.5, ENST00000343933.9

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl25676
Location:10 → 518

WD40_4; Type of WD40 repeat
NM_052820.4 → NP_438171.1 coronin-2A

See identical proteins and their annotated locations for NP_438171.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 1. Variants 1 and 2 encode the same protein and contain the same 3' UTR.

Source sequence(s)

AK292788, AL137073, BC011690, BM976925

Consensus CDS

CCDS6735.1

UniProtKB/Swiss-Prot

Q5TBR5, Q92828, Q92829, Q9BWS5

UniProtKB/TrEMBL

A8K9S3

Related

ENSP00000364218.4, ENST00000375077.5

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl25676
Location:10 → 518

WD40_4; Type of WD40 repeat