Nudt9 nudix hydrolase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt9provided by MGI
Official Full Name: nudix hydrolase 9provided by MGI
Primary source: MGI:MGI:1921417
See related: Ensembl:ENSMUSG00000029310 AllianceGenome:MGI:1921417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADPR-PPase; 1190002C07Rik
Summary: Enables ADP-ribose diphosphatase activity. Acts upstream of or within ADP catabolic process. Located in mitochondrion. Is expressed in alimentary system; cranium; liver; nervous system; and retina. Orthologous to human NUDT9 (nudix hydrolase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 57.6), adrenal adult (RPKM 40.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (104193407..104213244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (104045538..104065378)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADP-ribose hydrolysis is catalysed by NDP-sugar/alcohol pyrophosphatases of differing specificity, including a highly specific, low-K(m) ADP-ribose pyrophosphatase.
Title: The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ADP-ribose diphosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ADP catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribose pyrophosphatase, mitochondrial

Names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; adenosine diphosphoribose pyrophosphatase; nucleoside diphosphate-linked moiety X motif 9; nudix (nucleoside diphosphate linked moiety X)-type motif 9; nudix motif 9

NP_083070.2

EC 3.6.1.13

XP_006535319.1

EC 3.6.1.13

XP_006535320.1

EC 3.6.1.13

XP_030110706.1

EC 3.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028794.4 → NP_083070.2 ADP-ribose pyrophosphatase, mitochondrial

See identical proteins and their annotated locations for NP_083070.2

Status: VALIDATED

Source sequence(s)

AK158058, AL714024, BY237462

Consensus CDS

CCDS19482.1

UniProtKB/Swiss-Prot

A2AH31, Q3TZ68, Q8BVU5, Q8K1J4

Related

ENSMUSP00000031250.8, ENSMUST00000031250.14

Conserved Domains (1) summary

cd03670
Location:149 → 335

ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

104193407..104213244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535257.5 → XP_006535320.1 ADP-ribose pyrophosphatase, mitochondrial isoform X2

Conserved Domains (1) summary

cd03670
Location:111 → 274

ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
XM_006535256.5 → XP_006535319.1 ADP-ribose pyrophosphatase, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006535319.1

Conserved Domains (1) summary

cd03670
Location:99 → 285

ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
XM_030254846.2 → XP_030110706.1 ADP-ribose pyrophosphatase, mitochondrial isoform X3

Conserved Domains (1) summary

cd03670
Location:61 → 224

ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...