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    Ifitm5 interferon induced transmembrane protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 73835, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ifitm5provided by MGI
    Official Full Name
    interferon induced transmembrane protein 5provided by MGI
    Primary source
    MGI:MGI:1934923
    See related
    Ensembl:ENSMUSG00000025489 AllianceGenome:MGI:1934923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bril; DSPA1; Hrmp1; Hrtm1; 1110003J06Rik
    Summary
    Involved in bone mineralization; bone morphogenesis; and in utero embryonic development. Located in plasma membrane. Is expressed in several structures, including bone; genitourinary system; limb cartilage condensation; perichondrium; and spleen. Used to study osteogenesis imperfecta type 5. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 5. Orthologous to human IFITM5 (interferon induced transmembrane protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 9.7), lung adult (RPKM 2.0) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Ifitm5 in Genome Data Viewer
    Location:
    7 F5; 7 86.17 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140528871..140530156, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140948958..140950243, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E2853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148127673-148127984 Neighboring gene protein glucosylgalactosylhydroxylysine glucosidase Neighboring gene STARR-seq mESC enhancer starr_20461 Neighboring gene interferon induced transmembrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_20462 Neighboring gene interferon induced transmembrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC118415

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interferon-induced transmembrane protein 5
    Names
    bone-restricted interferon induced transmembrane protein-like protein
    dispanin subfamily A member 1
    fragilis family member 4
    haemopoiesis related membrane protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053088.3NP_444318.1  interferon-induced transmembrane protein 5

      See identical proteins and their annotated locations for NP_444318.1

      Status: VALIDATED

      Source sequence(s)
      BC103790, BY703620, FJ200451
      Consensus CDS
      CCDS21993.1
      UniProtKB/Swiss-Prot
      O88728
      Related
      ENSMUSP00000026562.5, ENSMUST00000026562.6
      Conserved Domains (1) summary
      pfam04505
      Location:2894
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140528871..140530156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)