thra thyroid hormone receptor alpha [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: thraprovided by Xenbase
Official Full Name: thyroid hormone receptor alphaprovided by Xenbase
Primary source: Xenbase:XB-GENE-5966551
See related: Ensembl:ENSXETG00000024399
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: erba; c-erba; TRalpha
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	10	NC_030686.2 (9063035..9190651, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	Unplaced Scaffold	NW_016683386.1 (217577..342687)

Chromosome 10 - NC_030686.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organ-specific effects on target binding due to knockout of thyroid hormone receptor alpha during Xenopus metamorphosis.
Title: Organ-specific effects on target binding due to knockout of thyroid hormone receptor α during Xenopus metamorphosis.
In TRbeta-knockout tadpoles, tail regression was delayed significantly and a healthy notochord was observed whereas in the tails of wild-type and TRalpha-knockout tadpoles, the notochord disappeared after approximately 1 day.
Title: Thyroid Hormone Receptor α- and β-Knockout Xenopus tropicalis Tadpoles Reveal Subtype-Specific Roles During Development.
A critical role of endogenous TRalpha, not only in regulating both the timing and rate of metamorphosis, but also in coordinating temporal metamorphosis of different organs.
Title: Thyroid Hormone Receptor α Controls Developmental Timing and Regulates the Rate and Coordination of Tissue-Specific Metamorphosis in Xenopus tropicalis.
As in the TRalpha null mouse model, TRalphaKO frogs had statistically significant but surprisingly mild growth and development phenotypes with normal survival and fertility.
Title: Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis.
unliganded TRalpha delays developmental progression by repressing TH-response genes
Title: Unliganded thyroid hormone receptor α regulates developmental timing via gene repression in Xenopus tropicalis.
roles in tadpole growth rate and the timing of metamorphosis
Title: Unliganded thyroid hormone receptor α controls developmental timing in Xenopus tropicalis.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyroid hormone receptor alpha

Names: thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045796.1 → NP_001039261.1 thyroid hormone receptor alpha

See identical proteins and their annotated locations for NP_001039261.1

Status: PROVISIONAL

Source sequence(s)

AB244213

UniProtKB/TrEMBL

A0A6I8Q1L2, Q0EDH8

Related

ENSXETP00000102977.1, ENSXETT00000122702.1

Conserved Domains (2) summary

cd06935
Location:171 → 412

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:60 → 146

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030686.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

9063035..9190651 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012952539.2 → XP_012807993.1 thyroid hormone receptor alpha isoform X1

See identical proteins and their annotated locations for XP_012807993.1

UniProtKB/TrEMBL

A0A6I8Q1L2, B3GR07, F6X4I6

Related

ENSXETP00000112529.1, ENSXETT00000116121.1

Conserved Domains (2) summary

cd06935
Location:171 → 412

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:60 → 146

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers