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    ITGAL integrin subunit alpha L [ Sus scrofa (pig) ]

    Gene ID: 733681, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ITGALprovided by VGNC
    Official Full Name
    integrin subunit alpha Lprovided by VGNC
    Primary source
    VGNC:VGNC:89240
    See related
    Ensembl:ENSSSCG00000007797
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in lung (RPKM 39.0), spleen (RPKM 38.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ITGAL in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (17817785..17858057, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (18259483..18299833)

    Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110259907 Neighboring gene zinc finger protein 768 Neighboring gene selenophosphate synthetase 2 Neighboring gene dCTP pyrophosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The wild boar (Sus scrofa) lymphocyte function-associated antigen-1 (CD11a/CD18) receptor: cDNA sequencing, structure analysis and comparison with homologues. Bergh PG, et al. BMC Vet Res, 2007 Oct 15. PMID 17937788, Free PMC Article
    2. Molecular cloning, characterization and gene expression of the full length cDNA encoding the porcine CD11b(αM) and chromosomal localization of the porcine CD11a(αL)-CD11b(αM)-CD11b(αD) gene cluster. Sanz G, et al. Vet Immunol Immunopathol, 2012 Jan 15. PMID 22129786
    3. The CD11a partner in Sus scrofa lymphocyte function-associated antigen-1 (LFA-1): mRNA cloning, structure analysis and comparison with mammalian homologues. Vanden Bergh PG, et al. BMC Vet Res, 2005 Oct 10. PMID 16216120, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular cloning, characterization, gene expression and chromosomal localization on region SSC3p15-17
      Title: Molecular cloning, characterization and gene expression of the full length cDNA encoding the porcine CD11b(αM) and chromosomal localization of the porcine CD11a(αL)-CD11b(αM)-CD11b(αD) gene cluster.
    2. The sequence and analysis of cDNAs encoding wild boar LFA-1 and the specificities of LFA-1 in this species that might confer resistance to Actinobacillus pleuropneumoniae are reported.
      Title: The wild boar (Sus scrofa) lymphocyte function-associated antigen-1 (CD11a/CD18) receptor: cDNA sequencing, structure analysis and comparison with homologues.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin alpha-L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044608.1 → NP_001038073.1  integrin alpha-L precursor

      See identical proteins and their annotated locations for NP_001038073.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ013284
      UniProtKB/TrEMBL
      Q30KI7, Q30KI8
      Related
      ENSSSCP00000029445.3, ENSSSCT00000032601.3
      Conserved Domains (4) summary
      smart00191
      Location:517 → 567
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:1112 → 1126
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:610 → 906
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:153 → 321
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

      Range
      17817785..17858057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005652999.3 → XP_005653056.2  integrin alpha-L isoform X1

      UniProtKB/TrEMBL
      A0A4X1TY54, A0A8D0P910, A0A8D2C0V0
      Related
      ENSSSCP00000008326.5, ENSSSCT00000008545.6
      Conserved Domains (4) summary
      smart00191
      Location:580 → 630
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:1174 → 1188
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:673 → 968
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:216 → 384
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_021085919.1 → XP_020941578.1  integrin alpha-L isoform X2

      UniProtKB/TrEMBL
      A0A8D0P6G6, A0A8D1TQN9
      Conserved Domains (4) summary
      smart00191
      Location:551 → 601
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:1146 → 1160
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:644 → 940
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:161 → 329
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

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