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    CEACAM18 CEA cell adhesion molecule 18 [ Homo sapiens (human) ]

    Gene ID: 729767, updated on 17-Sep-2024

    Summary

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    Official Symbol
    CEACAM18provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 18provided by HGNC
    Primary source
    HGNC:HGNC:31949
    See related
    Ensembl:ENSG00000213822 AllianceGenome:HGNC:31949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in duodenum (RPKM 5.4) and small intestine (RPKM 3.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See CEACAM18 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51478539..51491301)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54567160..54579923)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51981793..51994555)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51966471-51967219 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene Neighboring gene sialic acid binding Ig like lectin 26, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51990573-51990732 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51991976-51992156 Neighboring gene sialic acid binding Ig like lectin 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52002817-52003316 Neighboring gene sialic acid binding Ig like lectin 27, pseudogene Neighboring gene sialic acid binding Ig like lectin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The old CEACAMs find their new role in tumor immunotherapy. Han ZW, et al. Invest New Drugs, 2020 Dec. PMID 32488569
    2. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. Zebhauser R, et al. Genomics, 2005 Nov. PMID 16139472

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 18
    Names
    carcinoembryonic antigen related cell adhesion molecule 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405061.1 → NP_001391990.1  carcinoembryonic antigen-related cell adhesion molecule 18 precursor

      Status: VALIDATED

      Source sequence(s)
      AC020914
      UniProtKB/Swiss-Prot
      A8MTB9, C9JN24
      Related
      ENSP00000379738.4, ENST00000396477.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51478539..51491301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328435.1 → XP_054184410.1  carcinoembryonic antigen-related cell adhesion molecule 18 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54567160..54579923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321928.1 → XP_054177903.1  carcinoembryonic antigen-related cell adhesion molecule 18 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080405.1: Suppressed sequence

      Description
      NM_001080405.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001278392.2: Suppressed sequence

      Description
      NM_001278392.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MTB9.4 GenPept UniProtKB/Swiss-Prot:A8MTB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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