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    SPDYE6 speedy/RINGO cell cycle regulator family member E6 [ Homo sapiens (human) ]

    Gene ID: 729597, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPDYE6provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E6provided by HGNC
    Primary source
    HGNC:HGNC:35465
    See related
    Ensembl:ENSG00000260097 AllianceGenome:HGNC:35465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a cell cycle regulatory protein which plays an important role in cell cycle progression by binding and activating cyclin-dependent kinases. The encoded protein belongs to a family of cyclin-dependent kinase regulators that contain a speedy box domain which is required for cyclin-dependent kinase activation. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in testis (RPKM 6.2), spleen (RPKM 2.1) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SPDYE6 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102345746..102356444, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103663168..103673862, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101986186..101996889, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986717 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26426 Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene uncharacterized LOC100289561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18503 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102036787-102037328 Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Gopinathan L, et al. Results Probl Cell Differ, 2011. PMID 21630153
    2. CDK activation by non-cyclin proteins. Nebreda AR. Curr Opin Cell Biol, 2006 Apr. PMID 16488127
    3. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Chauhan S, et al. Cell Mol Life Sci, 2012 Nov. PMID 22763696, Free PMC Article
    4. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng A, et al. Cell Cycle, 2005 Jan. PMID 15611625
    5. Characterization of a new family of cyclin-dependent kinase activators. Dinarina A, et al. Biochem J, 2005 Mar 1. PMID 15574121, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speedy protein E6
    Names
    Putative speedy protein E6
    speedy homolog E6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146210.4 → NP_001139682.2  speedy protein E6

      See identical proteins and their annotated locations for NP_001139682.2

      Status: REVIEWED

      Source sequence(s)
      AC091390, HY053642
      Consensus CDS
      CCDS78265.1
      UniProtKB/Swiss-Prot
      A0A096LNU6, P0CI01
      Related
      ENSP00000485230.1, ENST00000563237.3
      Conserved Domains (1) summary
      pfam11357
      Location:194 → 398
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102345746..102356444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420794.1 → XP_047276750.1  speedy protein E6 isoform X2

      UniProtKB/Swiss-Prot
      A0A096LNU6, P0CI01

    2. XM_047420793.1 → XP_047276749.1  speedy protein E6 isoform X1

    3. XM_047420795.1 → XP_047276751.1  speedy protein E6 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103663168..103673862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358927.1 → XP_054214902.1  speedy protein E6 isoform X4

    2. XM_054358926.1 → XP_054214901.1  speedy protein E6 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CI01.2 GenPept UniProtKB/Swiss-Prot:P0CI01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials