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    Gpr160 G protein-coupled receptor 160 [ Mus musculus (house mouse) ]

    Gene ID: 71862, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gpr160provided by MGI
    Official Full Name
    G protein-coupled receptor 160provided by MGI
    Primary source
    MGI:MGI:1919112
    See related
    Ensembl:ENSMUSG00000037661 AllianceGenome:MGI:1919112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GPCR150; 1700025D19Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in trigeminal ganglion. Orthologous to human GPR160 (G protein-coupled receptor 160). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 54.6), large intestine adult (RPKM 20.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr160 in Genome Data Viewer
    Location:
    3 A3; 3 14.33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30909908..30951344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30855759..30897194)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SEC62 homolog, preprotein translocation Neighboring gene predicted gene, 42198 Neighboring gene predicted gene, 42199 Neighboring gene STARR-seq mESC enhancer starr_07303 Neighboring gene polyhomeotic 3 Neighboring gene STARR-positive B cell enhancer ABC_E4537 Neighboring gene predicted gene 2979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway. Fan S, et al. J Genet Genomics, 2024 Oct. PMID 38750952
    2. Behavioral characterization of G-protein-coupled receptor 160 knockout mice. Schafer RM, et al. Pain, 2024 Jun 1. PMID 38198232,
    3. G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells. Zhou C, et al. Oncotarget, 2016 Mar 15. PMID 26871479, Free PMC Article
    4. G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK. Yang H, et al. Cell Signal, 2016 Sep. PMID 27259691
    5. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. Lanier J, et al. Dev Dyn, 2009 Dec. PMID 19877281, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway.
      Title: GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway.
    2. Behavioral characterization of G-protein-coupled receptor 160 knockout mice.
      Title: Behavioral characterization of G-protein-coupled receptor 160 knockout mice.
    3. these findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway.
      Title: G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 160

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134385.2 → NP_001127857.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_001127857.1

      Status: VALIDATED

      Source sequence(s)
      AC111093, AC158135
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2
      Related
      ENSMUSP00000103893.2, ENSMUST00000108258.8

    2. NM_001134386.2 → NP_001127858.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_001127858.1

      Status: VALIDATED

      Source sequence(s)
      AC111093, BY207079
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2
      Related
      ENSMUSP00000128666.2, ENSMUST00000166278.7

    3. NM_001286994.1 → NP_001273923.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_001273923.1

      Status: VALIDATED

      Source sequence(s)
      AC111093, AC158135
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2
      Related
      ENSMUSP00000103896.2, ENSMUST00000108261.8

    4. NM_001286995.1 → NP_001273924.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_001273924.1

      Status: VALIDATED

      Source sequence(s)
      AC111093, AC158135
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2
      Related
      ENSMUSP00000103894.2, ENSMUST00000108259.8

    5. NM_001286996.1 → NP_001273925.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_001273925.1

      Status: VALIDATED

      Source sequence(s)
      AC111093, AC158135, BY208743
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    6. NM_001357144.1 → NP_001344073.1  probable G-protein coupled receptor 160

      Status: VALIDATED

      Source sequence(s)
      AC111093, AC158135
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    7. NM_027965.2 → NP_082241.1  probable G-protein coupled receptor 160

      See identical proteins and their annotated locations for NP_082241.1

      Status: VALIDATED

      Source sequence(s)
      AC111093, AC158135, AK006330
      Consensus CDS
      CCDS50883.1
      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2
      Related
      ENSMUSP00000045165.7, ENSMUST00000046748.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      30909908..30951344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319737.3 → XP_017175226.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    2. XM_030252832.2 → XP_030108692.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    3. XM_030252830.2 → XP_030108690.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    4. XM_017319735.3 → XP_017175224.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    5. XM_006535539.4 → XP_006535602.1  probable G-protein coupled receptor 160 isoform X1

      See identical proteins and their annotated locations for XP_006535602.1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    6. XM_017319734.3 → XP_017175223.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    7. XM_030252831.2 → XP_030108691.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2

    8. XM_036163339.1 → XP_036019232.1  probable G-protein coupled receptor 160 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F9, Q9D9Y9
      UniProtKB/TrEMBL
      Q14AX2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3F9.1 GenPept UniProtKB/Swiss-Prot:Q3U3F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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