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    Rab3b RAB3B, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 69908, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rab3bprovided by MGI
    Official Full Name
    RAB3B, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1917158
    See related
    Ensembl:ENSMUSG00000003411 AllianceGenome:MGI:1917158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610528C18Rik
    Summary
    Enables GTP-dependent protein binding activity. Acts upstream of or within peptidyl-cysteine methylation and regulation of exocytosis. Located in synaptic vesicle. Colocalizes with secretory granule. Is expressed in dentate gyrus subgranular zone and telencephalon. Orthologous to human RAB3B (RAB3B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 19.6), frontal lobe adult (RPKM 19.1) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab3b in Genome Data Viewer
    Location:
    4 C7; 4 50.67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108736267..108800521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108879070..108943324)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11052 Neighboring gene basic transcription factor 3-like 4 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated Neighboring gene STARR-seq mESC enhancer starr_11058 Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene nardilysin convertase Neighboring gene microRNA 761 Neighboring gene STARR-seq mESC enhancer starr_11061 Neighboring gene STARR-seq mESC enhancer starr_11062 Neighboring gene oxysterol binding protein-like 9 Neighboring gene predicted gene, 32581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Tsetsenis T, et al. Proc Natl Acad Sci U S A, 2011 Aug 23. PMID 21844341, Free PMC Article
    2. Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis. Bubier JA, et al. Front Neurosci, 2020. PMID 32742255, Free PMC Article
    3. Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells. Nishimura N, et al. Arch Biochem Biophys, 2008 Jun 1. PMID 18396146
    4. A complete genetic analysis of neuronal Rab3 function. Schlüter OM, et al. J Neurosci, 2004 Jul 21. PMID 15269275, Free PMC Article
    5. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. Schlüter OM, et al. J Neurosci, 2006 Jan 25. PMID 16436611, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Presynaptic forms of long-term plasticity at excitatory and inhibitory synapses generally are mediated by a common Rab3/RIM-dependent pathway, with various types of synapses using distinct Rab3 isoforms.
      Title: Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning.
    2. Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation.
      Title: The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
    3. Gas8 was specifically interacted with the GTP-bound form of Rab3B and co-localized with Rab3B at the Golgi in NIH 3T3 cells
      Title: Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells.
    4. Rab3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range.
      Title: Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-cysteine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of dopamine uptake involved in synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dopaminergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023537.5 → NP_076026.1  ras-related protein Rab-3B

      See identical proteins and their annotated locations for NP_076026.1

      Status: PROVISIONAL

      Source sequence(s)
      AL607070
      Consensus CDS
      CCDS18459.1
      UniProtKB/Swiss-Prot
      Q80WV9, Q920F1, Q9CZT8
      UniProtKB/TrEMBL
      A2A7Z6, Q0PD62
      Related
      ENSMUSP00000102261.3, ENSMUST00000106650.9
      Conserved Domains (1) summary
      cd01865
      Location:22 → 186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108736267..108800521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164406.1 → XP_036020299.1  ras-related protein Rab-3B isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1 → 91
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZT8.1 GenPept UniProtKB/Swiss-Prot:Q9CZT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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