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    Ints14 integrator complex subunit 14 [ Mus musculus (house mouse) ]

    Gene ID: 69882, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ints14provided by MGI
    Official Full Name
    integrator complex subunit 14provided by MGI
    Primary source
    MGI:MGI:1917132
    See related
    Ensembl:ENSMUSG00000034263 AllianceGenome:MGI:1917132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vwa9; 2010321M09Rik
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Is expressed in cerebral cortex ventricular layer and heart ventricle. Orthologous to human INTS14 (integrator complex subunit 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.6), limb E14.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints14 in Genome Data Viewer
    Location:
    9 C; 9 35.02 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64868143..64894260)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64960832..64986981)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4A Neighboring gene predicted gene, 24347 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Neighboring gene predicted gene, 39361 Neighboring gene STARR-positive B cell enhancer ABC_E1789 Neighboring gene predicted gene, 25640 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene predicted gene, 39362

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 14
    Names
    UPF0464 protein C15orf44 homolog
    von Willebrand factor A domain containing 9
    von Willebrand factor A domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077631.3 → NP_001071099.1  integrator complex subunit 14 isoform 1

      See identical proteins and their annotated locations for NP_001071099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122463
      Consensus CDS
      CCDS40668.1
      UniProtKB/Swiss-Prot
      Q3THM0, Q3V323, Q3V3E8, Q8C072, Q8R3P6
      Related
      ENSMUSP00000127420.2, ENSMUST00000170517.9
      Conserved Domains (2) summary
      pfam13519
      Location:3 → 117
      VWA_2; von Willebrand factor type A domain
      cl17190
      Location:365 → 489
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_001416261.1 → NP_001403190.1  integrator complex subunit 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122463
      UniProtKB/Swiss-Prot
      Q3THM0, Q3V323, Q3V3E8, Q8C072, Q8R3P6

    3. NM_001416262.1 → NP_001403191.1  integrator complex subunit 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122463

    4. NM_001416263.1 → NP_001403192.1  integrator complex subunit 14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122463

    5. NM_001416264.1 → NP_001403193.1  integrator complex subunit 14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122463

    6. NM_001416265.1 → NP_001403194.1  integrator complex subunit 14 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122463

    7. NM_175153.5 → NP_780362.2  integrator complex subunit 14 isoform 1

      See identical proteins and their annotated locations for NP_780362.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122463
      Consensus CDS
      CCDS40668.1
      UniProtKB/Swiss-Prot
      Q3THM0, Q3V323, Q3V3E8, Q8C072, Q8R3P6
      Related
      ENSMUSP00000049284.6, ENSMUST00000037504.7
      Conserved Domains (2) summary
      pfam13519
      Location:3 → 117
      VWA_2; von Willebrand factor type A domain
      cl17190
      Location:365 → 489
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64868143..64894260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3P6.1 GenPept UniProtKB/Swiss-Prot:Q8R3P6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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