Capns2 calpain, small subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Capns2provided by MGI
Official Full Name: calpain, small subunit 2provided by MGI
Primary source: MGI:MGI:1916793
See related: Ensembl:ENSMUSG00000078144 AllianceGenome:MGI:1916793
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 30K-2; 2310005G05Rik
Summary: Predicted to enable calcium ion binding activity and calcium-dependent cysteine-type endopeptidase activity. Predicted to be located in plasma membrane. Predicted to be part of calpain complex. Orthologous to human CAPNS2 (calpain small subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 44.99 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (93628023..93629037)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (92901395..92902409)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of calpain complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: calpain small subunit 2

Names: CSS2; calcium-dependent protease small subunit 2

NP_081388.1

EC 3.4.22.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027112.1 → NP_081388.1 calpain small subunit 2

See identical proteins and their annotated locations for NP_081388.1

Status: VALIDATED

Source sequence(s)

AA612262, AK009171, BB571460

Consensus CDS

CCDS52634.1

UniProtKB/Swiss-Prot

Q9D7J7

Related

ENSMUSP00000100553.3, ENSMUST00000104947.5

Conserved Domains (2) summary

pfam13499
Location:154 → 209

EF-hand_7; EF-hand domain pair

cl08302
Location:123 → 168

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...