Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajb13provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member B13provided by MGI
Primary source: MGI:MGI:1916637
See related: Ensembl:ENSMUSG00000030708 AllianceGenome:MGI:1916637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsarg; 1700014P03Rik
Summary: Predicted to enable chaperone binding activity and unfolded protein binding activity. Predicted to be involved in axonemal central apparatus assembly and chaperone cofactor-dependent protein refolding. Predicted to act upstream of or within cell projection organization. Located in axoneme and sperm connecting piece. Is expressed in several structures, including brain ventricle and choroid plexus; ventricular layer; and white fat. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 160.4) and ovary adult (RPKM 6.8) See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.36 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100152218..100182834, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100503011..100514815, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that DNAJB13 participates in spermiogenesis and the motility of mature spermatozoa.
Title: DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis.
By multi-tissue reverse transcription polymerase chain reaction, we found that Dnajb13 gene was expressed not only in the testis but also in several other ciliated cell-containing tissues like brain, lung and oviduct.
Title: DNAJB13 is a radial spoke protein of mouse '9+2' axoneme.
The interaction of DNAJB13 with SEPT4 in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure.
Title: Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development.
DNAJB13 might be involved in assembly and stability of axoneme during sperm flagellum development.
Title: A heat-shock protein 40, DNAJB13, is an axoneme-associated component in mouse spermatozoa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Dcr43 (e-PCR), detects polymorphism
- UniSTS:507802

D7Mit96 (e-PCR), detects polymorphism
- UniSTS:131301

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonemal central apparatus assembly	ISO Inferred from Sequence Orthology more info
involved_in axonemal central apparatus assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IC Inferred by Curator more info	PubMed
involved_in flagellated sperm motility	IC Inferred by Curator more info	PubMed
involved_in mating	IC Inferred by Curator more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	IC Inferred by Curator more info	PubMed
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
part_of radial spoke	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IC Inferred by Curator more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm head-tail coupling apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dnaJ homolog subfamily B member 13

Names: DnaJ (Hsp40) related, subfamily B, member 13; spermatogenesis apoptosis-related protein; testis and spermatogenesis cell-related protein 6; testis spermatocyte apoptosis-related gene 6 protein; testis spermatogenesis apoptosis-related gene 3 protein; testis spermatogenesis apoptosis-related gene 6 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153527.3 → NP_705755.2 dnaJ homolog subfamily B member 13

See identical proteins and their annotated locations for NP_705755.2

Status: VALIDATED

Source sequence(s)

AC117215

Consensus CDS

CCDS21499.1

UniProtKB/Swiss-Prot

Q80Y75, Q8CJA2

UniProtKB/TrEMBL

A0A171EBK9

Related

ENSMUSP00000147019.2, ENSMUST00000207405.2

Conserved Domains (3) summary

cd10747
Location:138 → 302

DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

COG0484
Location:1 → 312

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:4 → 65

DnaJ; DnaJ domain

RNA

NR_184865.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117215

Related

ENSMUST00000154516.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

100152218..100182834 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153418.1 → XP_036009311.1 dnaJ homolog subfamily B member 13 isoform X2

Conserved Domains (1) summary

cd10747
Location:31 → 157

DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
XM_006508184.3 → XP_006508247.1 dnaJ homolog subfamily B member 13 isoform X1

UniProtKB/TrEMBL

A0A171EBK9

Conserved Domains (1) summary

COG0484
Location:18 → 307

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]