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    Efcab9 EF-hand calcium binding domain 9 [ Mus musculus (house mouse) ]

    Gene ID: 69306, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Efcab9provided by MGI
    Official Full Name
    EF-hand calcium binding domain 9provided by MGI
    Primary source
    MGI:MGI:1916556
    See related
    Ensembl:ENSMUSG00000044056 AllianceGenome:MGI:1916556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700007I06Rik; 4930403C08Rik
    Summary
    Enables calcium ion binding activity and calcium ion sensor activity. Involved in flagellated sperm motility and sperm capacitation. Located in cytoplasm and sperm principal piece. Part of CatSper complex. Orthologous to human EFCAB9 (EF-hand calcium binding domain 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 38.3) and spleen adult (RPKM 1.8) See more
    Orthologs
    human all
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    Genomic context

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    See Efcab9 in Genome Data Viewer
    Location:
    11 A4; 11 18.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32472733..32483144, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32522733..32533240, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51948 Neighboring gene ubiquitin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32442680-32442833 Neighboring gene serine/threonine kinase 10 Neighboring gene STARR-positive B cell enhancer ABC_E5214 Neighboring gene F-box and WD-40 domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_29115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella. Yang F, et al. Development, 2022 Jan 15. PMID 34919125, Free PMC Article
    2. 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Zhao Y, et al. Nat Commun, 2022 Jun 17. PMID 35715406, Free PMC Article
    3. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, et al. Cell Rep, 2022 Jan 18. PMID 34998468, Free PMC Article
    4. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Hwang JY, et al. Cell, 2019 May 30. PMID 31056283, Free PMC Article
    5. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC107247

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CatSper complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027031.3 → NP_081307.2  EF-hand calcium-binding domain-containing protein 9

      See identical proteins and their annotated locations for NP_081307.2

      Status: VALIDATED

      Source sequence(s)
      AV260313, BC087911
      Consensus CDS
      CCDS24528.1
      UniProtKB/Swiss-Prot
      Q9D5P6, Q9DAM2
      Related
      ENSMUSP00000060205.3, ENSMUST00000054327.3
      Conserved Domains (2) summary
      COG5126
      Location:33 → 162
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13499
      Location:108 → 162
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      32472733..32483144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243747.4 → XP_011242049.1  EF-hand calcium-binding domain-containing protein 9 isoform X1

      See identical proteins and their annotated locations for XP_011242049.1

      UniProtKB/Swiss-Prot
      Q9D5P6, Q9DAM2
      Conserved Domains (2) summary
      COG5126
      Location:33 → 162
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13499
      Location:108 → 162
      EF-hand_7; EF-hand domain pair

    2. XM_036156961.1 → XP_036012854.1  EF-hand calcium-binding domain-containing protein 9 isoform X2

      Conserved Domains (1) summary
      pfam13499
      Location:43 → 97
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAM2.2 GenPept UniProtKB/Swiss-Prot:Q9DAM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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