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    Start1 Steroidogenic acute regulatory protein-like [ Bombyx mori (domestic silkworm) ]

    Gene ID: 692547, updated on 10-Oct-2024

    Summary

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    Gene symbol
    Start1
    Gene description
    Steroidogenic acute regulatory protein-like
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bombyx mori
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
    Also known as
    Cbp
    Orthologs
    fruit fly all
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    Genomic context

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    See Start1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 2 NC_085108.1 (6375583..6416504)
    103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 2 NC_051359.1 (6366141..6407060)

    Chromosome 2 - NC_085108.1Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase UGT33R2 Neighboring gene uncharacterized LOC105842582 Neighboring gene uncharacterized LOC119629498 Neighboring gene uncharacterized LOC134200522 Neighboring gene histone H1 Neighboring gene uncharacterized LOC101736380

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of a silkworm F₁ hybrid with yellow cocoon generated by crossing two white-cocoon strains: further evidences for the roles of Cameo2 and CBP in formation of yellow cocoon. Chai C, et al. Gene, 2014 Jan 15. PMID 24157262
    2. BmStart1, a novel carotenoid-binding protein isoform from Bombyx mori, is orthologous to MLN64, a mammalian cholesterol transporter. Sakudoh T, et al. Biochem Biophys Res Commun, 2005 Nov 4. PMID 16169523
    3. 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori. Lyu H, et al. Insect Mol Biol, 2020 Apr. PMID 31840914
    4. Combined effect of Cameo2 and CBP on the cellular uptake of lutein in the silkworm, Bombyx mori. Wang W, et al. PLoS One, 2014. PMID 24475153, Free PMC Article
    5. Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of the Yellow blood gene. Sakudoh T, et al. Proc Natl Acad Sci U S A, 2007 May 22. PMID 17496138, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori.
      Title: 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori.
    2. Cameo2 and CBP are necessarily expressed in midguts and silk glands for lutein uptake in Bombyx mori.
      Title: Combined effect of Cameo2 and CBP on the cellular uptake of lutein in the silkworm, Bombyx mori.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in vesicle tethering to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum-endosome membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carotenoid-binding protein
    Names
    putative cholesterol transporter BmStart1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043533.2 → NP_001036998.2  carotenoid-binding protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB211534, BABH01017793
      UniProtKB/TrEMBL
      A0A8R1XEG7, Q3V5Y6
      Conserved Domains (2) summary
      cd08868
      Location:246 → 470
      START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins
      pfam10457
      Location:49 → 227
      MENTAL; Cholesterol-capturing domain

    2. NM_001110362.2 → NP_001103832.2  carotenoid-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK377911
      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM3026992v2 Primary Assembly

    Genomic

    1. NC_085108.1 Reference ASM3026992v2 Primary Assembly

      Range
      6375583..6416504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038014834.2 → XP_037870762.1  carotenoid-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8R1XEG7, Q3V5Y6
      Conserved Domains (2) summary
      cd08868
      Location:246 → 470
      START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins
      pfam10457
      Location:49 → 227
      MENTAL; Cholesterol-capturing domain

    2. XM_062671785.1 → XP_062527769.1  carotenoid-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8R1XEG7

    3. XM_038014875.2 → XP_037870803.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    4. XM_038014854.2 → XP_037870782.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    5. XM_038014841.2 → XP_037870769.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    6. XM_038014844.2 → XP_037870772.1  carotenoid-binding protein isoform X4

      UniProtKB/TrEMBL
      A0A8R2QYW6, X2F9Z2
      Conserved Domains (1) summary
      cd08868
      Location:2 → 224
      START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins

    7. XM_038014843.2 → XP_037870771.1  carotenoid-binding protein isoform X3

      UniProtKB/TrEMBL
      A0A8R2M050, X2F9Z2
      Conserved Domains (1) summary
      cd08868
      Location:6 → 228
      START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins

    8. XM_038014876.2 → XP_037870804.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    9. XM_038014865.2 → XP_037870793.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    10. XM_062671796.1 → XP_062527780.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8

    11. XM_038014872.2 → XP_037870800.1  carotenoid-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8R2QWT8, X2F9Z2
      Conserved Domains (1) summary
      cl14643
      Location:1 → 212
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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