Qrich1 glutamine-rich 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Qrich1provided by MGI
Official Full Name: glutamine-rich 1provided by MGI
Primary source: MGI:MGI:1916482
See related: Ensembl:ENSMUSG00000006673 AllianceGenome:MGI:1916482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: b2b2404Clo; 2610028H07Rik
Summary: Predicted to enable DNA binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within kidney development. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; facial prominence; female reproductive system; spleen; and urinary system. Orthologous to human QRICH1 (glutamine rich 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 54.1), ovary adult (RPKM 39.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.45 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108394010..108437366)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108516982..108560167)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126847 (e-PCR)
- UniSTS:208453

C86287 (e-PCR)
- UniSTS:208454

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in PERK-mediated unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrated stress response signaling	ISO Inferred from Sequence Orthology more info
involved_in integrated stress response signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcriptional regulator QRICH1

Names: glutamine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114119.1 → NP_001107591.1 transcriptional regulator QRICH1

See identical proteins and their annotated locations for NP_001107591.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK151491, BB851544, BF658891, CT010508

Consensus CDS

CCDS52927.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Related

ENSMUSP00000006851.9, ENSMUST00000006851.15

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
NM_175143.5 → NP_780352.2 transcriptional regulator QRICH1

See identical proteins and their annotated locations for NP_780352.2

Status: VALIDATED

Description

Transcript Variant: This variant lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK151491, BB851544, BC120916, BF658891

Consensus CDS

CCDS52927.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Related

ENSMUSP00000107782.4, ENSMUST00000112155.9

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108394010..108437366

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511809.4 → XP_006511872.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511872.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_030244560.2 → XP_030100420.1 transcriptional regulator QRICH1 isoform X2

UniProtKB/Swiss-Prot

Q3UA37

Conserved Domains (1) summary

pfam12012
Location:507 → 667

DUF3504; Domain of unknown function (DUF3504)
XM_006511808.4 → XP_006511871.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511871.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_017313561.3 → XP_017169050.1 transcriptional regulator QRICH1 isoform X4

Conserved Domains (2) summary

pfam12012
Location:256 → 416

DUF3504; Domain of unknown function (DUF3504)

cl14633
Location:6 → 45

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006511813.4 → XP_006511876.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511876.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_006511812.3 → XP_006511875.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511875.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_006511811.5 → XP_006511874.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511874.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_006511814.3 → XP_006511877.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511877.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_006511818.2 → XP_006511881.1 transcriptional regulator QRICH1 isoform X4

See identical proteins and their annotated locations for XP_006511881.1

Conserved Domains (2) summary

pfam12012
Location:256 → 416

DUF3504; Domain of unknown function (DUF3504)

cl14633
Location:6 → 45

DD; Death Domain Superfamily of protein-protein interaction domains
XM_036155242.1 → XP_036011135.1 transcriptional regulator QRICH1 isoform X2

UniProtKB/Swiss-Prot

Q3UA37

Conserved Domains (1) summary

pfam12012
Location:507 → 667

DUF3504; Domain of unknown function (DUF3504)
XM_006511810.4 → XP_006511873.1 transcriptional regulator QRICH1 isoform X1

See identical proteins and their annotated locations for XP_006511873.1

UniProtKB/Swiss-Prot

Q3UA37

UniProtKB/TrEMBL

G3X8R5

Conserved Domains (2) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

pfam12012
Location:606 → 759

DUF3504; Domain of unknown function (DUF3504)
XM_036155244.1 → XP_036011137.1 transcriptional regulator QRICH1 isoform X4

Conserved Domains (2) summary

pfam12012
Location:256 → 416

DUF3504; Domain of unknown function (DUF3504)

cl14633
Location:6 → 45

DD; Death Domain Superfamily of protein-protein interaction domains
XM_017313560.3 → XP_017169049.1 transcriptional regulator QRICH1 isoform X2

UniProtKB/Swiss-Prot

Q3UA37

Conserved Domains (1) summary

pfam12012
Location:507 → 667

DUF3504; Domain of unknown function (DUF3504)
XM_030244561.2 → XP_030100421.1 transcriptional regulator QRICH1 isoform X4

Conserved Domains (2) summary

pfam12012
Location:256 → 416

DUF3504; Domain of unknown function (DUF3504)

cl14633
Location:6 → 45

DD; Death Domain Superfamily of protein-protein interaction domains
XM_036155243.1 → XP_036011136.1 transcriptional regulator QRICH1 isoform X3

UniProtKB/TrEMBL

Q8BUN3

Related

ENSMUSP00000141267.2, ENSMUST00000193258.6

Conserved Domains (1) summary

cd01671
Location:6 → 45

CARD; Caspase activation and recruitment domain: a protein-protein interaction domain