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    Xpnpep3 X-prolyl aminopeptidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685823, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Xpnpep3provided by RGD
    Official Full Name
    X-prolyl aminopeptidase 3provided by RGD
    Primary source
    RGD:1589063
    See related
    EnsemblRapid:ENSRNOG00000019196 AllianceGenome:RGD:1589063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    APP3
    Summary
    Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within glomerular filtration and protein processing. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 64.7), Heart (RPKM 60.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Xpnpep3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114806398..114858934)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112926154..112978793)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122636252..122686983)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 17 Neighboring gene uncharacterized LOC134479943 Neighboring gene ST13, Hsp70 interacting protein Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene ribosomal protein L37A, pseudogene 2 Neighboring gene transfer RNA proline (anticodon AGG) 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes. Singh R, et al. J Biol Chem, 2017 Jun 16. PMID 28476889, Free PMC Article
    2. Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2. Inoue M, et al. J Cell Sci, 2015 Feb 15. PMID 25609706
    3. Processing of mitochondrial presequences. Mossmann D, et al. Biochim Biophys Acta, 2012 Sep-Oct. PMID 22172993
    4. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. O'Toole JF, et al. J Clin Invest, 2010 Mar. PMID 20179356, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188876

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glomerular filtration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 3
    Names
    X-Pro aminopeptidase 3
    X-prolyl aminopeptidase 3, mitochondrial
    aminopeptidase P3
    probable Xaa-Pro aminopeptidase 3
    NP_001124054.3
    XP_006242183.1
    XP_038935832.1
    XP_038935833.1
    XP_063120333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130582.3 → NP_001124054.3  xaa-Pro aminopeptidase 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      B5DEQ3
      UniProtKB/TrEMBL
      A0A8I6GA16, A6HSZ7
      Related
      ENSRNOP00000082871.2, ENSRNOT00000111293.2
      Conserved Domains (2) summary
      smart01011
      Location:67 → 206
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:252 → 489
      Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      114806398..114858934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264263.1 → XP_063120333.1  xaa-Pro aminopeptidase 3 isoform X1

    2. XM_006242121.5 → XP_006242183.1  xaa-Pro aminopeptidase 3 isoform X2

      See identical proteins and their annotated locations for XP_006242183.1

      UniProtKB/Swiss-Prot
      B5DEQ3
      UniProtKB/TrEMBL
      A6HSZ9
      Conserved Domains (2) summary
      smart01011
      Location:15 → 127
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:173 → 410
      Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

    3. XM_039079904.2 → XP_038935832.1  xaa-Pro aminopeptidase 3 isoform X2

      UniProtKB/Swiss-Prot
      B5DEQ3
      UniProtKB/TrEMBL
      A6HSZ9
      Conserved Domains (2) summary
      smart01011
      Location:15 → 127
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:173 → 410
      Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

    4. XM_039079905.2 → XP_038935833.1  xaa-Pro aminopeptidase 3 isoform X3

      Conserved Domains (1) summary
      cd01087
      Location:1 → 235
      Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DEQ3.1 GenPept UniProtKB/Swiss-Prot:B5DEQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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