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    Cryga crystallin, gamma A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684028, updated on 17-Aug-2024

    Summary

    Symbol
    Crygaprovided by RGD
    Full Name
    crystallin, gamma Aprovided by RGD
    Primary source
    RGD:1595217
    See related
    EnsemblRapid:ENSRNOG00000046343 AllianceGenome:RGD:1595217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Orthologous to human CRYGA (crystallin gamma A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 34.6), Brain (RPKM 18.9) and 1 other tissue See more
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    Genomic context

    Location:
    9q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73975914..74006614, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66482176..66484638, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71828308..71855900, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene crystallin, gamma C Neighboring gene crystallin, gamma B Neighboring gene transfer RNA proline (anticodon AGG) 73 Neighboring gene isocitrate dehydrogenase (NADP(+)) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within eye development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lens development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    gamma-crystallin A
    Names
    CRY-gamma-A
    gamma-A-crystallin
    gamma-crystallin 1-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080936.2NP_001074405.1  gamma-crystallin A

      See identical proteins and their annotated locations for NP_001074405.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P10065
      Related
      ENSRNOP00000019963.3, ENSRNOT00000019963.5
      Conserved Domains (2) summary
      smart00247
      Location:382
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89170
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      73975914..74006614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267734.1XP_063123804.1  gamma-crystallin A isoform X2

      Related
      ENSRNOP00000107573.1, ENSRNOT00000146939.1
    2. XM_063267735.1XP_063123805.1  gamma-crystallin A isoform X3

    3. XM_063267733.1XP_063123803.1  gamma-crystallin A isoform X1

      UniProtKB/TrEMBL
      A6IPJ4, M0R5G4
      Related
      ENSRNOP00000064629.3, ENSRNOT00000072983.4
    4. XM_063267736.1XP_063123806.1  gamma-crystallin A isoform X4

    5. XM_063267737.1XP_063123807.1  gamma-crystallin A isoform X4

    6. XM_063267738.1XP_063123808.1  gamma-crystallin A isoform X5

    RNA

    1. XR_010054633.1 RNA Sequence