Rab13 RAB13, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab13provided by MGI
Official Full Name: RAB13, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1927232
See related: Ensembl:ENSMUSG00000027935 AllianceGenome:MGI:1927232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610007N03Rik; B230212B15Rik
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase A catalytic subunit binding activity. Involved in endocytic recycling; endothelial cell chemotaxis; and protein localization to cell leading edge. Located in several cellular components, including bicellular tight junction; endocytic vesicle; and lamellipodium. Is expressed in several structures, including brain; early conceptus; meninges; secondary oocyte; and small intestine. Orthologous to human RAB13 (RAB13, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 5.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.21 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90121022..90133694)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90213715..90226387)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal proteomics identifies RAB13 as a potential regulator of metastasis for HCC.
Title: Exosomal proteomics identifies RAB13 as a potential regulator of metastasis for HCC.
Rab13 acts with Mst1 to regulate the spatial distribution of LFA-1 and the motility and trafficking of lymphocytes
Title: Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.
Rab13 associates with Grb2, targeting Syx and RhoA to Tyr(1175)-phosphorylated VEGFR2 at the leading edge.
Title: Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.
Rab13 and Rab8A are Rab-GTPases activated by insulin and downstream of AS160 they regulate traffic of GLUT4 vesicles.
Title: Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rab13 (e-PCR), detects polymorphism
- UniSTS:281110

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of Sertoli cell barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of Sertoli cell barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cell leading edge	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in trans-Golgi network to recycling endosome transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in insulin-responsive compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293741.1 → NP_001280670.1 ras-related protein Rab-13 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the use of an alternate promoter, has a different 5' structure, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC119825, AI529508, AK080805

Consensus CDS

CCDS79962.1

UniProtKB/TrEMBL

D3YUS4

Related

ENSMUSP00000102996.2, ENSMUST00000107373.8

Conserved Domains (1) summary

cl21455
Location:1 → 91

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_026677.4 → NP_080953.1 ras-related protein Rab-13 isoform 1

See identical proteins and their annotated locations for NP_080953.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC119825, AI529508, AK002303, AK080805, BB867138

Consensus CDS

CCDS17522.1

UniProtKB/Swiss-Prot

Q9DD03

UniProtKB/TrEMBL

Q0PD42

Related

ENSMUSP00000070588.7, ENSMUST00000065418.7

Conserved Domains (2) summary

smart00175
Location:9 → 170

RAB; Rab subfamily of small GTPases

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)