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    Rlig1 RNA 5'-phosphate and 3'-OH ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68281, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rlig1provided by MGI
    Official Full Name
    RNA 5'-phosphate and 3'-OH ligase 1provided by MGI
    Primary source
    MGI:MGI:1921197
    See related
    Ensembl:ENSMUSG00000046567 AllianceGenome:MGI:1921197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnl; 4930430F08Rik; 4930571E09Rik; A730088G13Rik; C430008C19Rik
    Summary
    Predicted to enable RNA ligase (ATP) activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Is expressed in liver lobe; nervous system; and thymus primordium. Orthologous to human RLIG1 (RNA 5'-phosphate and 3'-OH ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 4.0), testis adult (RPKM 3.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rlig1 in Genome Data Viewer
    Location:
    10 D1; 10 51.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (100408136..100425252, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (100572274..100589390, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene THO complex 4 pseudogene Neighboring gene transmembrane and tetratricopeptide repeat containing 3 Neighboring gene STARR-seq mESC enhancer starr_27735 Neighboring gene centrosomal protein 290 Neighboring gene RIKEN cDNA 1700017N19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr10:100051814-100052115 Neighboring gene STARR-positive B cell enhancer mm9_chr10:100092429-100092730 Neighboring gene STARR-seq mESC enhancer starr_27736 Neighboring gene predicted gene, 35722

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA ligase (ATP) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein adenylylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    RNA ligase 1
    Names
    RNA ligase
    uncharacterized protein C12orf29 homolog
    NP_780337.2
    XP_006514091.1
    XP_036011864.1
    XP_036011865.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175128.2 → NP_780337.2  RNA ligase 1

      See identical proteins and their annotated locations for NP_780337.2

      Status: VALIDATED

      Source sequence(s)
      AK160693, BC082587, CJ178338
      Consensus CDS
      CCDS24151.1
      UniProtKB/Swiss-Prot
      Q8BHN7, Q8BHP8, Q8BHV9
      Related
      ENSMUSP00000062410.9, ENSMUST00000054471.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      100408136..100425252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514028.5 → XP_006514091.1  RNA ligase 1 isoform X3

      Conserved Domains (1) summary
      pfam17720
      Location:1 → 264
      DUF5565; Family of unknown function (DUF5565)

    2. XM_036155971.1 → XP_036011864.1  RNA ligase 1 isoform X1

      Conserved Domains (1) summary
      pfam17720
      Location:1 → 346
      DUF5565; Family of unknown function (DUF5565)

    3. XM_036155972.1 → XP_036011865.1  RNA ligase 1 isoform X2

      Conserved Domains (1) summary
      pfam17720
      Location:1 → 284
      DUF5565; Family of unknown function (DUF5565)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHN7.1 GenPept UniProtKB/Swiss-Prot:Q8BHN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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