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    Gstz1 glutathione S-transferase zeta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681913, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gstz1provided by RGD
    Official Full Name
    glutathione S-transferase zeta 1provided by RGD
    Primary source
    RGD:1589363
    See related
    EnsemblRapid:ENSRNOG00000047708 AllianceGenome:RGD:1589363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glutathione transferase activity; maleylacetoacetate isomerase activity; and protein homodimerization activity. Involved in cellular detoxification. Is active in cytosol and mitochondrial matrix. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1483.3), Kidney (RPKM 463.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gstz1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112525576..112536228)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106794594..106805284)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111176798..111187246)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene neuroglobin Neighboring gene protein-O-mannosyltransferase 2 Neighboring gene uncharacterized LOC134479237 Neighboring gene transmembrane p24 trafficking protein family member 8 Neighboring gene sterile alpha motif domain containing 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration. Jahn SC, et al. Biochem Pharmacol, 2018 Jun. PMID 29626439, Free PMC Article
    2. Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Polekhina G, et al. Biochemistry, 2001 Feb 13. PMID 11327815
    3. Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. Blackburn AC, et al. Pharmacogenetics, 2000 Feb. PMID 10739172
    4. Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Tong Z, et al. Biochem J, 1998 Apr 15. PMID 9531472, Free PMC Article
    5. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. Li W, et al. J Pharmacol Exp Ther, 2011 Jan. PMID 20884751, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study evaluated the metabolism of dichloroacetic acid in liver, hear, brain, and kidney via GSTZ1.
      Title: Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.
    2. The mitochondrion is a second site of dichloroacetate biotransformation in a reaction catalyzed by GSTZ1, an enzyme colocalized in the mitochondrial matrix and cytosol.
      Title: Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables maleylacetoacetate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables maleylacetoacetate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maleylacetoacetate isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular detoxification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tyrosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    maleylacetoacetate isomerase
    Names
    GSTZ1-1
    MAAI
    glutathione S-transferase alpha 3
    glutathione transferase zeta 1
    NP_001102915.1
    XP_006240461.1
    XP_038968853.1
    XP_063118542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109445.1 → NP_001102915.1  maleylacetoacetate isomerase

      See identical proteins and their annotated locations for NP_001102915.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/Swiss-Prot
      B0BNI1, P57113
      Related
      ENSRNOP00000065390.2, ENSRNOT00000072215.4
      Conserved Domains (3) summary
      cd03191
      Location:93 → 207
      GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
      cd03042
      Location:6 → 80
      GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      TIGR01262
      Location:7 → 211
      maiA; maleylacetoacetate isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112525576..112536228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112925.2 → XP_038968853.1  maleylacetoacetate isomerase isoform X2

      Conserved Domains (1) summary
      TIGR01262
      Location:58 → 191
      maiA; maleylacetoacetate isomerase

    2. XM_006240399.5 → XP_006240461.1  maleylacetoacetate isomerase isoform X1

      See identical proteins and their annotated locations for XP_006240461.1

      UniProtKB/TrEMBL
      A0A0G2K6H2, A6JE83
      Related
      ENSRNOP00000073813.1, ENSRNOT00000082027.3
      Conserved Domains (1) summary
      TIGR01262
      Location:6 → 210
      maiA; maleylacetoacetate isomerase

    3. XM_063262472.1 → XP_063118542.1  maleylacetoacetate isomerase isoform X3

      UniProtKB/TrEMBL
      A6JE85
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57113.2 GenPept UniProtKB/Swiss-Prot:P57113

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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