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    Puf60 poly-U binding splicing factor 60 [ Mus musculus (house mouse) ]

    Gene ID: 67959, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Puf60provided by MGI
    Official Full Name
    poly-U binding splicing factor 60provided by MGI
    Primary source
    MGI:MGI:1915209
    See related
    Ensembl:ENSMUSG00000002524 AllianceGenome:MGI:1915209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIAHBP1; 2410104I19Rik; 2810454F19Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; mRNA splice site recognition; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human PUF60 (poly(U) binding splicing factor 60). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 127.4), adrenal adult (RPKM 124.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Puf60 in Genome Data Viewer
    Location:
    15 D3; 15 35.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75942031..75954386, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76070182..76082537, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83, member H Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene scribbled planar cell polarity Neighboring gene microRNA 6952 Neighboring gene STARR-seq mESC enhancer starr_39038 Neighboring gene predicted gene, 48952 Neighboring gene nuclear receptor binding protein 2 Neighboring gene predicted gene, 41349

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway. Rahmutulla B, et al. Oncotarget, 2014 May 15. PMID 24811221, Free PMC Article
    2. Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Matsushita K, et al. Oncotarget, 2015 Mar 10. PMID 25671302, Free PMC Article
    3. Analysis of phosphorylation-dependent protein-protein interactions of histone h3. Klingberg R, et al. ACS Chem Biol, 2015 Jan 16. PMID 25330109
    4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
    5. The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn Y, et al. Biochem J, 2008 Jun 1. PMID 18307411

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(U)-binding-splicing factor PUF60
    Names
    60 kDa poly(U)-binding-splicing factor
    fuse-binding protein-interacting repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164600.1 → NP_001158072.1  poly(U)-binding-splicing factor PUF60 isoform c

      See identical proteins and their annotated locations for NP_001158072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC116487, AK168789, AW488875
      UniProtKB/Swiss-Prot
      Q3UEB3
      Conserved Domains (1) summary
      TIGR01645
      Location:1 → 499
      half-pint; poly-U binding splicing factor, half-pint family

    2. NM_001356629.2 → NP_001343558.1  poly(U)-binding-splicing factor PUF60 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:2 → 557
      half-pint; poly-U binding splicing factor, half-pint family

    3. NM_001378984.1 → NP_001365913.1  poly(U)-binding-splicing factor PUF60 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:9 → 563
      half-pint; poly-U binding splicing factor, half-pint family

    4. NM_001378985.1 → NP_001365914.1  poly(U)-binding-splicing factor PUF60 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:9 → 546
      half-pint; poly-U binding splicing factor, half-pint family

    5. NM_001378986.1 → NP_001365915.1  poly(U)-binding-splicing factor PUF60 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:2 → 540
      half-pint; poly-U binding splicing factor, half-pint family

    6. NM_001403043.1 → NP_001389972.1  poly(U)-binding-splicing factor PUF60 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC116487

    7. NM_001403044.1 → NP_001389973.1  poly(U)-binding-splicing factor PUF60 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC116487

    8. NM_001403045.1 → NP_001389974.1  poly(U)-binding-splicing factor PUF60 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC116487

    9. NM_001403046.1 → NP_001389975.1  poly(U)-binding-splicing factor PUF60 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC116487

    10. NM_028364.3 → NP_082640.2  poly(U)-binding-splicing factor PUF60 isoform a

      See identical proteins and their annotated locations for NP_082640.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC116487
      Consensus CDS
      CCDS37112.1
      UniProtKB/Swiss-Prot
      Q3TGC6, Q3UEB3, Q91VR6
      Related
      ENSMUSP00000098096.5, ENSMUST00000100527.13
      Conserved Domains (1) summary
      TIGR01645
      Location:7 → 564
      half-pint; poly-U binding splicing factor, half-pint family

    11. NM_133691.6 → NP_598452.2  poly(U)-binding-splicing factor PUF60 isoform b

      See identical proteins and their annotated locations for NP_598452.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC116487
      Consensus CDS
      CCDS37111.1
      UniProtKB/Swiss-Prot
      Q3UEB3
      Related
      ENSMUSP00000002599.10, ENSMUST00000002599.11
      Conserved Domains (1) summary
      TIGR01645
      Location:7 → 547
      half-pint; poly-U binding splicing factor, half-pint family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75942031..75954386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248718.1 → XP_030104578.1  poly(U)-binding-splicing factor PUF60 isoform X1

      Conserved Domains (1) summary
      TIGR01645
      Location:41 → 598
      half-pint; poly-U binding splicing factor, half-pint family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UEB3.2 GenPept UniProtKB/Swiss-Prot:Q3UEB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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