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    Limd2 LIM domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 67803, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Limd2provided by MGI
    Official Full Name
    LIM domain containing 2provided by MGI
    Primary source
    MGI:MGI:1915053
    See related
    Ensembl:ENSMUSG00000040699 AllianceGenome:MGI:1915053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610025L06Rik
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in actin cytoskeleton and plasma membrane. Is expressed in central nervous system; foregut; genitourinary system; and sensory organ. Orthologous to human LIMD2 (LIM domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 154.4), thymus adult (RPKM 102.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Limd2 in Genome Data Viewer
    Location:
    11 E1; 11 68.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106047080..106051555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106156254..106160729, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:105927234-105927440 Neighboring gene STARR-seq mESC enhancer starr_30915 Neighboring gene STARR-positive B cell enhancer ABC_E2372 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene STARR-positive B cell enhancer ABC_E258 Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene STE20-related kinase adaptor alpha Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene coiled-coil domain containing 47

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LIM domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356458.1 → NP_001343387.1  LIM domain-containing protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL596331, BC068130, CF738656
      Consensus CDS
      CCDS25549.1
      UniProtKB/Swiss-Prot
      Q8BGB5
      Related
      ENSMUSP00000102488.2, ENSMUST00000106875.2
      Conserved Domains (1) summary
      cd09486
      Location:41 → 93
      LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

    2. NM_001356459.1 → NP_001343388.1  LIM domain-containing protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC068130, BU697882, BY078132, CF738656
      Consensus CDS
      CCDS25549.1
      UniProtKB/Swiss-Prot
      Q8BGB5
      Related
      ENSMUSP00000067070.5, ENSMUST00000064545.11
      Conserved Domains (1) summary
      cd09486
      Location:41 → 93
      LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

    3. NM_172397.4 → NP_765985.1  LIM domain-containing protein 2

      See identical proteins and their annotated locations for NP_765985.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL596331, BC068130, CF738656
      Consensus CDS
      CCDS25549.1
      UniProtKB/Swiss-Prot
      Q8BGB5
      Related
      ENSMUSP00000045357.4, ENSMUST00000045923.10
      Conserved Domains (1) summary
      cd09486
      Location:41 → 93
      LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106047080..106051555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGB5.1 GenPept UniProtKB/Swiss-Prot:Q8BGB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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