U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 [ Mus musculus (house mouse) ]

    Gene ID: 67713, updated on 9-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dnajc19provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C19provided by MGI
    Primary source
    MGI:MGI:1914963
    See related
    Ensembl:ENSMUSG00000027679 AllianceGenome:MGI:1914963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tim14; 1810055D05Rik
    Summary
    Predicted to enable ATPase activator activity. Involved in regulation of cardiolipin metabolic process. Located in matrix side of mitochondrial inner membrane. Part of inner mitochondrial membrane protein complex. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to human DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 15.5), duodenum adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dnajc19 in Genome Data Viewer
    Location:
    3 A3; 3 16.43 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (34111429..34135503, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (34057280..34081354, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07364 Neighboring gene predicted gene, 46833 Neighboring gene STARR-seq mESC enhancer starr_07366 Neighboring gene calcium regulated heat stable protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07367 Neighboring gene FMR1 autosomal homolog 1 Neighboring gene STARR-seq mESC enhancer starr_07368 Neighboring gene SET translocation pseudogene Neighboring gene predicted gene, 52623

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Richter-Dennerlein R, et al. Cell Metab, 2014 Jul 1. PMID 24856930
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in genitalia development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cardiolipin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PAM complex, Tim23 associated import motor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner mitochondrial membrane protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in matrix side of mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mitochondrial import inner membrane translocase subunit TIM14
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 19

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001026211.2 → NP_001021382.1  mitochondrial import inner membrane translocase subunit TIM14 isoform 2

      See identical proteins and their annotated locations for NP_001021382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC068294, AK008267, CA469052
      Consensus CDS
      CCDS38411.1
      UniProtKB/TrEMBL
      G3X8S1
      Related
      ENSMUSP00000011029.6, ENSMUST00000011029.12
      Conserved Domains (1) summary
      cl02542
      Location:55 → 94
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    2. NM_001286972.1 → NP_001273901.1  mitochondrial import inner membrane translocase subunit TIM14 isoform 3

      See identical proteins and their annotated locations for NP_001273901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a 3' terminal exon that extends past a splice site that is used in variant 2. This results in a novel 3' coding region and 3' UTR compared to variant 2. It encodes isoform 3 which is shorter and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC068294, CA469052, EL962106
      Consensus CDS
      CCDS71233.1
      UniProtKB/Swiss-Prot
      Q9CQV7
      Related
      ENSMUSP00000113484.2, ENSMUST00000117223.4
      Conserved Domains (1) summary
      cl02542
      Location:55 → 94
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    3. NM_001286973.1 → NP_001273902.1  mitochondrial import inner membrane translocase subunit TIM14 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 2. These differences result in a distinct 5' UTR and a different 3' structure and cause translation initiation at an alternate start codon compared to variant 2. The encoded protein (isoform 4) has distinct N- and C-termini and is shorter than isoform 2.
      Source sequence(s)
      AK007866, CA469052, CJ123658
      Consensus CDS
      CCDS71234.1
      UniProtKB/TrEMBL
      D3Z5K6
      Related
      ENSMUSP00000113514.2, ENSMUST00000120805.8
      Conserved Domains (1) summary
      cl02542
      Location:49 → 104
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    4. NM_026332.4 → NP_080608.3  mitochondrial import inner membrane translocase subunit TIM14 isoform 1

      See identical proteins and their annotated locations for NP_080608.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 3' terminal exon which results in a frameshift compared to variant 2. The resulting protein (isoform 1) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AC068294, AK007866, CA469052
      Consensus CDS
      CCDS38412.1
      UniProtKB/Swiss-Prot
      Q8R1N1, Q9CQV7, Q9D896
      Related
      ENSMUSP00000103830.4, ENSMUST00000108195.10
      Conserved Domains (1) summary
      cl02542
      Location:55 → 110
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      34111429..34135503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQV7.3 GenPept UniProtKB/Swiss-Prot:Q9CQV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools