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    Ost4 oligosaccharyltransferase complex subunit 4 (non-catalytic) [ Mus musculus (house mouse) ]

    Gene ID: 67695, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ost4provided by MGI
    Official Full Name
    oligosaccharyltransferase complex subunit 4 (non-catalytic)provided by MGI
    Primary source
    MGI:MGI:1914945
    See related
    Ensembl:ENSMUSG00000038803 AllianceGenome:MGI:1914945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310016E02Rik
    Summary
    Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be part of oligosaccharyltransferase complex. Is expressed in Meckel's cartilage; cerebral cortex ventricular layer; and orbito-sphenoid. Orthologous to human OST4 (oligosaccharyltransferase complex subunit 4, non-catalytic). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 157.9), genital fat pad adult (RPKM 151.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ost4 in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31063860..31065155, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30906516..30907807, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35795 Neighboring gene nuclear encoded tRNA alanine 15 (anticodon AGC) Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene ATP/GTP binding protein-like 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31218364-31218473 Neighboring gene elastin microfibril interfacer 1 Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
    2. Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line. Chu VT, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27729526, Free PMC Article
    3. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
    Names
    oligosaccharyltransferase 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134692.2 → NP_001128164.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

      See identical proteins and their annotated locations for NP_001128164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC082316, BU756604, DV041491
      Consensus CDS
      CCDS39049.1
      UniProtKB/Swiss-Prot
      Q99LX8
      Related
      ENSMUSP00000126221.2, ENSMUST00000132034.5
      Conserved Domains (1) summary
      pfam10215
      Location:1 → 34
      Ost4; Oligosaccaryltransferase

    2. NM_024460.4 → NP_077780.3  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

      See identical proteins and their annotated locations for NP_077780.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003569, BU756604, DV041491
      Consensus CDS
      CCDS39049.1
      UniProtKB/Swiss-Prot
      Q99LX8
      Related
      ENSMUSP00000128352.2, ENSMUST00000132253.5
      Conserved Domains (1) summary
      pfam10215
      Location:1 → 34
      Ost4; Oligosaccaryltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31063860..31065155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504071.5 → XP_006504134.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006504134.1

      UniProtKB/Swiss-Prot
      Q99LX8
      Conserved Domains (1) summary
      pfam10215
      Location:1 → 34
      Ost4; Oligosaccaryltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LX8.1 GenPept UniProtKB/Swiss-Prot:Q99LX8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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