Ctdp1 CTD phosphatase subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctdp1provided by MGI
Official Full Name: CTD phosphatase subunit 1provided by MGI
Primary source: MGI:MGI:1926953
See related: Ensembl:ENSMUSG00000033323 AllianceGenome:MGI:1926953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930563P03Rik
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity; TFIIF-class transcription factor complex binding activity; and Tat protein binding activity. Predicted to be involved in several processes, including exit from mitosis; negative regulation of cell growth involved in cardiac muscle cell development; and positive regulation by host of viral transcription. Predicted to be located in microtubule cytoskeleton; midbody; and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in several structures, including heart; liver; lung; nervous system; and spleen. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 3.7), ovary adult (RPKM 3.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 53.48 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (80451174..80522959, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (80407959..80478739, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.
Title: Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW553592 (e-PCR)
- UniSTS:186136

NoName (e-PCR)
- UniSTS:237856

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	ISO Inferred from Sequence Orthology more info
enables TFIIF-class transcription factor complex binding	IEA Inferred from Electronic Annotation more info
enables TFIIF-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
enables Tat protein binding	IEA Inferred from Electronic Annotation more info
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA polymerase II subunit A C-terminal domain phosphatase

Names: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; TFIIF-associating CTD phosphatase

NP_080571.2

EC 3.1.3.16

XP_006526588.1

EC 3.1.3.16

XP_011245398.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026295.3 → NP_080571.2 RNA polymerase II subunit A C-terminal domain phosphatase

See identical proteins and their annotated locations for NP_080571.2

Status: VALIDATED

Source sequence(s)

BC053435, BY239926

Consensus CDS

CCDS29368.1

UniProtKB/Swiss-Prot

Q7TSG2, Q7TSS7, Q9D4S8

UniProtKB/TrEMBL

Q3U0S4

Related

ENSMUSP00000038938.7, ENSMUST00000036229.13

Conserved Domains (4) summary

TIGR02250
Location:177 → 323

FCP1_euk; FCP1-like phosphatase, phosphatase domain

cd06850
Location:27 → 111

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd00027
Location:637 → 706

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

pfam09309
Location:706 → 960

FCP1_C; FCP1, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

80451174..80522959 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526525.5 → XP_006526588.1 RNA polymerase II subunit A C-terminal domain phosphatase isoform X1

UniProtKB/TrEMBL

Q3U0S4

Conserved Domains (4) summary

TIGR02250
Location:177 → 323

FCP1_euk; FCP1-like phosphatase, phosphatase domain

cd06850
Location:27 → 111

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd17729
Location:611 → 713

BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins

pfam09309
Location:706 → 799

FCP1_C; FCP1, C-terminal
XM_011247096.2 → XP_011245398.1 RNA polymerase II subunit A C-terminal domain phosphatase isoform X2

See identical proteins and their annotated locations for XP_011245398.1

UniProtKB/TrEMBL

Q3U0S4

Conserved Domains (3) summary

TIGR02250
Location:58 → 204

FCP1_euk; FCP1-like phosphatase, phosphatase domain

cd17729
Location:492 → 594

BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins

pfam09309
Location:587 → 841

FCP1_C; FCP1, C-terminal