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    Spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 67629, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spc24provided by MGI
    Official Full Name
    SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1914879
    See related
    Ensembl:ENSMUSG00000074476 AllianceGenome:MGI:1914879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spbc24; 2410030K01Rik
    Summary
    Predicted to contribute to microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in brain ventricular layer and cerebral cortex. Orthologous to human SPC24 (SPC24 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 17.7), liver E14.5 (RPKM 17.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spc24 in Genome Data Viewer
    Location:
    9 A3; 9 7.88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21666730..21671741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21755434..21760446, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26511 Neighboring gene STARR-positive B cell enhancer ABC_E10537 Neighboring gene STARR-positive B cell enhancer ABC_E1109 Neighboring gene low density lipoprotein receptor Neighboring gene STARR-positive B cell enhancer ABC_E1379 Neighboring gene STARR-seq mESC enhancer starr_23515 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene dedicator of cytokinesis 6 Neighboring gene predicted gene, 39305

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs. Zhang T, et al. Oncotarget, 2016 Nov 1. PMID 27713128, Free PMC Article
    2. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Ciferri C, et al. Cell, 2008 May 2. PMID 18455984, Free PMC Article
    3. Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Baumgartner M, et al. Development, 2018 Aug 28. PMID 30093551, Free PMC Article
    4. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article
    5. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spc24 plays an important role in genomic stability maintenance during oocyte meiotic maturation.
      Title: Spc24 is required for meiotic kinetochore-microtubule attachment and production of euploid eggs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ndc80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Spc24
    Names
    spindle pole body component 24 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357331.1 → NP_001344260.1  kinetochore protein Spc24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC161371, BC056965
      Consensus CDS
      CCDS90517.1
      UniProtKB/TrEMBL
      A0A1L1SV84
      Related
      ENSMUSP00000151082.2, ENSMUST00000216057.2
      Conserved Domains (2) summary
      pfam08286
      Location:83 → 129
      Spc24; Spc24 subunit of Ndc80
      cl25732
      Location:35 → 129
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_026282.6 → NP_080558.1  kinetochore protein Spc24 isoform 1

      See identical proteins and their annotated locations for NP_080558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161371, AK011728
      Consensus CDS
      CCDS40554.1
      UniProtKB/Swiss-Prot
      Q3TIF5, Q8CD13, Q9D083
      UniProtKB/TrEMBL
      Q14BA9
      Related
      ENSMUSP00000096541.5, ENSMUST00000098942.6
      Conserved Domains (2) summary
      pfam01496
      Location:40 → 124
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam08286
      Location:83 → 192
      Spc24; Spc24 subunit of Ndc80

    RNA

    1. NR_151672.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161371

    2. NR_151673.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161371

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21666730..21671741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003947984.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D083.1 GenPept UniProtKB/Swiss-Prot:Q9D083

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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