Ttll4 tubulin tyrosine ligase-like family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttll4provided by MGI
Official Full Name: tubulin tyrosine ligase-like family, member 4provided by MGI
Primary source: MGI:MGI:1914784
See related: Ensembl:ENSMUSG00000033257 AllianceGenome:MGI:1914784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0173; 4632407P03Rik
Summary: Enables tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Acts upstream of or within regulation of blastocyst development. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in 1-cell stage embryo; 8-cell stage embryo; and blastocyst. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 16.4), CNS E11.5 (RPKM 10.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 38.54 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74700804..74740991)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74661645..74701832)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Klf4 polyglutamylation plays a critical role in the regulation of cell reprogramming and pluripotency maintenance in a process that involves TTLL4 and TTLL1
Title: Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

41.MMHAP75FRF11.seq (e-PCR)
- UniSTS:124425

MHAa64b12.seq (e-PCR)
- UniSTS:125250

AI451681 (e-PCR)
- UniSTS:158812

NoName (e-PCR)
- UniSTS:234156

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-glutamic acid ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-glutamic acid ligase activity, initiating	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables tubulin-glutamic acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-glutamic acid modification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein polyglutamylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyglutamylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein polyglutamylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in 9+0 non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin monoglutamylase TTLL4

Names: polyglutamylase; protein monoglutamylase TTLL4; tubulin polyglutamylase TTLL4; tubulin--tyrosine ligase-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.