Pagr1a PAXIP1 associated glutamate rich protein 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pagr1aprovided by MGI
Official Full Name: PAXIP1 associated glutamate rich protein 1Aprovided by MGI
Primary source: MGI:MGI:1914528
See related: Ensembl:ENSMUSG00000107068 AllianceGenome:MGI:1914528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PA1; PAGR1; 2900092E17Rik
Summary: Predicted to enable nuclear estrogen receptor binding activity. Involved in DNA damage response; positive regulation of isotype switching to IgG isotypes; and regulation of cell cycle G2/M phase transition. Acts upstream of or within chorion development. Part of histone methyltransferase complex. Is expressed in several structures, including extraembryonic component. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 90.4), CNS E11.5 (RPKM 43.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.27 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126614223..126616524, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127015051..127017352, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPbeta and C/EBPdelta.
Title: MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.
a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
Title: A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage.
Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
PA1 (also known as C16orf53 in human and 2900092E17Rik in mouse) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135947 (e-PCR)
- UniSTS:209943

RH126087 (e-PCR)
- UniSTS:162799

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chorion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle G1/S phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G2/M phase transition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MLL3/4 complex	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: PAXIP1-associated glutamate-rich protein 1A

Names: PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated 1; PTIP-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030240.1 → NP_084516.1 PAXIP1-associated glutamate-rich protein 1A

See identical proteins and their annotated locations for NP_084516.1

Status: PROVISIONAL

Source sequence(s)

BC003932

Consensus CDS

CCDS21854.1

UniProtKB/Swiss-Prot

Q99L02

Related

ENSMUSP00000144243.2, ENSMUST00000202798.2

Conserved Domains (1) summary

pfam15364
Location:85 → 216

PAXIP1_C; PAXIP1-associated-protein-1 C term PTIP binding protein