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    Ccdc77 coiled-coil domain containing 77 [ Mus musculus (house mouse) ]

    Gene ID: 67200, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc77provided by MGI
    Official Full Name
    coiled-coil domain containing 77provided by MGI
    Primary source
    MGI:MGI:1914450
    See related
    Ensembl:ENSMUSG00000030177 AllianceGenome:MGI:1914450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2400002C23Rik; 2700091N06Rik
    Summary
    Predicted to be active in centrosome. Orthologous to human CCDC77 (coiled-coil domain containing 77). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.9), liver E14 (RPKM 4.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc77 in Genome Data Viewer
    Location:
    6 F1; 6 56.95 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120301283..120341330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120324322..120364369, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ninjurin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2801 Neighboring gene STARR-positive B cell enhancer ABC_E2802 Neighboring gene predicted gene, 25327 Neighboring gene STARR-positive B cell enhancer ABC_E10405 Neighboring gene STARR-seq mESC enhancer starr_17164 Neighboring gene STARR-positive B cell enhancer ABC_E6477 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3 Neighboring gene STARR-seq mESC enhancer starr_17178 Neighboring gene STARR-seq mESC enhancer starr_17179 Neighboring gene STARR-seq mESC enhancer starr_17181 Neighboring gene STARR-positive B cell enhancer ABC_E3675 Neighboring gene STARR-positive B cell enhancer ABC_E11334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120314296-120314483 Neighboring gene lysine demethylase 5A Neighboring gene predicted gene, 24592 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120416743-120416991 Neighboring gene STARR-positive B cell enhancer ABC_E685 Neighboring gene STARR-positive B cell enhancer ABC_E10406 Neighboring gene interleukin 17 receptor A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 77

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381934.1 → NP_001368863.1  coiled-coil domain-containing protein 77 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155720
      UniProtKB/Swiss-Prot
      Q8VEJ7, Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:46 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001381935.1 → NP_001368864.1  coiled-coil domain-containing protein 77 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155720
      Conserved Domains (1) summary
      TIGR02168
      Location:28 → 359
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_001381936.1 → NP_001368865.1  coiled-coil domain-containing protein 77 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155720
      Related
      ENSMUSP00000108323.2, ENSMUST00000112703.8
      Conserved Domains (1) summary
      TIGR02168
      Location:28 → 359
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. NM_001381937.1 → NP_001368866.1  coiled-coil domain-containing protein 77 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC155720
      Conserved Domains (1) summary
      pfam15921
      Location:28 → 434
      CCDC158; Coiled-coil domain-containing protein 158

    5. NM_001381938.1 → NP_001368867.1  coiled-coil domain-containing protein 77 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC155720
      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 268
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. NM_026028.5 → NP_080304.1  coiled-coil domain-containing protein 77 isoform 1

      See identical proteins and their annotated locations for NP_080304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AK012598, AK031590, BU757887, CD555913
      Consensus CDS
      CCDS20481.1
      UniProtKB/Swiss-Prot
      Q8VEJ7, Q9CZH8
      Related
      ENSMUSP00000032283.6, ENSMUST00000032283.12
      Conserved Domains (1) summary
      TIGR02168
      Location:46 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. NR_045558.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) difers in the 5' UTR and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK031590, BU757887, CX205399
      Related
      ENSMUST00000127146.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      120301283..120341330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506495.3 → XP_006506558.1  coiled-coil domain-containing protein 77 isoform X2

      See identical proteins and their annotated locations for XP_006506558.1

      UniProtKB/Swiss-Prot
      Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:28 → 359
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006506490.4 → XP_006506553.1  coiled-coil domain-containing protein 77 isoform X1

      See identical proteins and their annotated locations for XP_006506553.1

      UniProtKB/Swiss-Prot
      Q8VEJ7, Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:46 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006506494.4 → XP_006506557.1  coiled-coil domain-containing protein 77 isoform X2

      See identical proteins and their annotated locations for XP_006506557.1

      UniProtKB/Swiss-Prot
      Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:28 → 359
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006506491.5 → XP_006506554.1  coiled-coil domain-containing protein 77 isoform X1

      See identical proteins and their annotated locations for XP_006506554.1

      UniProtKB/Swiss-Prot
      Q8VEJ7, Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:46 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_006506500.5 → XP_006506563.1  coiled-coil domain-containing protein 77 isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:54 → 405
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_006506499.4 → XP_006506562.1  coiled-coil domain-containing protein 77 isoform X3

      See identical proteins and their annotated locations for XP_006506562.1

      Conserved Domains (1) summary
      TIGR02168
      Location:52 → 355
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_011241435.3 → XP_011239737.1  coiled-coil domain-containing protein 77 isoform X3

      See identical proteins and their annotated locations for XP_011239737.1

      Conserved Domains (1) summary
      TIGR02168
      Location:52 → 355
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_011241439.4 → XP_011239741.1  coiled-coil domain-containing protein 77 isoform X5

      See identical proteins and their annotated locations for XP_011239741.1

      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 268
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_011241432.4 → XP_011239734.1  coiled-coil domain-containing protein 77 isoform X1

      See identical proteins and their annotated locations for XP_011239734.1

      UniProtKB/Swiss-Prot
      Q8VEJ7, Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:46 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. XM_011241433.4 → XP_011239735.1  coiled-coil domain-containing protein 77 isoform X2

      See identical proteins and their annotated locations for XP_011239735.1

      UniProtKB/Swiss-Prot
      Q9CZH8
      Conserved Domains (1) summary
      TIGR02168
      Location:28 → 359
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. XM_036152269.1 → XP_036008162.1  coiled-coil domain-containing protein 77 isoform X5

      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 268
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_011241434.1 → XP_011239736.1  coiled-coil domain-containing protein 77 isoform X3

      See identical proteins and their annotated locations for XP_011239736.1

      Conserved Domains (1) summary
      TIGR02168
      Location:52 → 355
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_004933618.1 RNA Sequence

    2. XR_001785160.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZH8.1 GenPept UniProtKB/Swiss-Prot:Q9CZH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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