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    Zcrb1 zinc finger CCHC-type and RNA binding motif 1 [ Mus musculus (house mouse) ]

    Gene ID: 67197, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zcrb1provided by MGI
    Official Full Name
    zinc finger CCHC-type and RNA binding motif 1provided by MGI
    Primary source
    MGI:MGI:1914447
    See related
    Ensembl:ENSMUSG00000022635 AllianceGenome:MGI:1914447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Madp-1; 2700088M22Rik
    Summary
    Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U12-type spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human ZCRB1 (zinc finger CCHC-type and RNA binding motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 46.2), CNS E14 (RPKM 26.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zcrb1 in Genome Data Viewer
    Location:
    15 E3; 15 47.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (93283987..93296218, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (93386106..93398341, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene YY1 associated factor 2 Neighboring gene predicted gene, 52193 Neighboring gene predicted gene, 26371 Neighboring gene STARR-seq mESC enhancer starr_39524 Neighboring gene STARR-positive B cell enhancer ABC_E11788 Neighboring gene periphilin 1 Neighboring gene predicted gene, 30181 Neighboring gene STARR-seq mESC enhancer starr_39526 Neighboring gene STARR-seq mESC enhancer starr_39528 Neighboring gene STARR-seq mESC enhancer starr_39531 Neighboring gene prickle planar cell polarity protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:93382836-93383019 Neighboring gene STARR-seq mESC enhancer starr_39536 Neighboring gene STARR-seq mESC enhancer starr_39537

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U12-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC-type and RNA-binding motif-containing protein 1
    Names
    U11/U12 small nuclear ribonucleoprotein 31 kDa protein
    U11/U12 snRNP 31 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347097.1 → NP_001334026.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126556, AI325876, AI666574
      Consensus CDS
      CCDS84190.1
      UniProtKB/Swiss-Prot
      Q9CZ96
      Related
      ENSMUSP00000124549.2, ENSMUST00000162160.8

    2. NM_026025.3 → NP_080301.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080301.1

      Status: VALIDATED

      Source sequence(s)
      AC126556, AI666574, AK012852
      Consensus CDS
      CCDS27766.1
      UniProtKB/Swiss-Prot
      Q3TDL3, Q9CZ96
      Related
      ENSMUSP00000075441.3, ENSMUST00000076070.9
      Conserved Domains (2) summary
      PTZ00368
      Location:97 → 123
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cd12393
      Location:9 → 84
      RRM_ZCRB1; RNA recognition motif (RRM) found in Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      93283987..93296218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245713.4 → XP_011244015.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X1

      Conserved Domains (2) summary
      PTZ00368
      Location:56 → 82
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_030248711.2 → XP_030104571.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X2

      Conserved Domains (2) summary
      PTZ00368
      Location:56 → 82
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ96.1 GenPept UniProtKB/Swiss-Prot:Q9CZ96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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