Pus3 pseudouridine synthase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pus3provided by MGI
Official Full Name: pseudouridine synthase 3provided by MGI
Primary source: MGI:MGI:1914299
See related: Ensembl:ENSMUSG00000032103 AllianceGenome:MGI:1914299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610020J05Rik; 5730412F04Rik
Summary: Enables pseudouridine synthase activity. Acts upstream of or within tRNA pseudouridine synthesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart ventricle; pharyngo-tympanic tube; pituitary gland; and vertebral axis musculature. Orthologous to human PUS3 (pseudouridine synthase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 8.0), CNS E14 (RPKM 6.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.32 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (35469856..35478697)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (35558560..35567401)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pus1p- and Pus3p-dependent pseudouridylation of SRA controls a coactivator-corepressor switch in SRA with major consequences for NR signaling.
Title: Pus3p- and Pus1p-dependent pseudouridylation of steroid receptor RNA activator controls a functional switch that regulates nuclear receptor signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236089

Hyls1 (e-PCR), detects polymorphism
- UniSTS:528054

RH47976 (e-PCR)
- UniSTS:47549

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudouridine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables pseudouridine synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA pseudouridine(38/39) synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA pseudouridine(38/39) synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA pseudouridine synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA pseudouridine(38/39) synthase

Names: tRNA pseudouridine synthase 3; tRNA pseudouridylate synthase 3; tRNA-uridine isomerase 3

NP_075781.3

EC 5.4.99.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023292.5 → NP_075781.3 tRNA pseudouridine(38/39) synthase

See identical proteins and their annotated locations for NP_075781.3

Status: VALIDATED

Source sequence(s)

AC118232

Consensus CDS

CCDS22965.1

UniProtKB/Swiss-Prot

Q8BVA6, Q8K0Y3, Q9JI38

Related

ENSMUSP00000034615.3, ENSMUST00000034615.10

Conserved Domains (2) summary

cd02569
Location:68 → 330

PseudoU_synth_ScPus3; Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like

COG0101
Location:66 → 336

TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]