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    Kcng4 potassium voltage-gated channel, subfamily G, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 66733, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kcng4provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily G, member 4provided by MGI
    Primary source
    MGI:MGI:1913983
    See related
    Ensembl:ENSMUSG00000045246 AllianceGenome:MGI:1913983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KV6.3; KV6.4; 4921535I01Rik
    Summary
    Predicted to enable delayed rectifier potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina inner nuclear layer. Orthologous to human KCNG4 (potassium voltage-gated channel modifier subfamily G member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 22.8), testis adult (RPKM 5.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcng4 in Genome Data Viewer
    Location:
    8 E1; 8 68.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120350593..120362497, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119623854..119635680, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1772 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C Neighboring gene STARR-seq mESC enhancer starr_22857 Neighboring gene adenosine deaminase domain containing 2 Neighboring gene predicted gene, 46055 Neighboring gene predicted gene, 46054 Neighboring gene predicted gene, 32352 Neighboring gene WAP four-disulfide core domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis. Regnier G, et al. Reprod Fertil Dev, 2017 Aug. PMID 27677211
    2. Cell firing between ON alpha retinal ganglion cells and coupled amacrine cells in the mouse retina. Wang Q, et al. Am J Physiol Cell Physiol, 2024 Sep 1. PMID 39010839
    3. Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na(+) Channel Isoforms. Smith BJ, et al. J Neurosci, 2023 Mar 29. PMID 36828637, Free PMC Article
    4. Gap junctional coupling between retinal amacrine and ganglion cells underlies coherent activity integral to global object perception. Roy K, et al. Proc Natl Acad Sci U S A, 2017 Nov 28. PMID 29133423, Free PMC Article
    5. Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures. Krieger B, et al. PLoS One, 2017. PMID 28753612, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNG4; potassium voltage-gated channel subfamily G member 4
    Names
    voltage-gated potassium channel subunit Kv6.3
    voltage-gated potassium channel subunit Kv6.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357210.1 → NP_001344139.1  voltage-gated potassium channel regulatory subunit KCNG4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104882
      Conserved Domains (1) summary
      cl38908
      Location:58 → 167
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. NM_025734.2 → NP_080010.2  voltage-gated potassium channel regulatory subunit KCNG4 isoform 1

      See identical proteins and their annotated locations for NP_080010.2

      Status: VALIDATED

      Source sequence(s)
      BC043936
      Consensus CDS
      CCDS22710.1
      UniProtKB/Swiss-Prot
      Q80XM3
      Related
      ENSMUSP00000056552.4, ENSMUST00000061828.10
      Conserved Domains (2) summary
      cl38908
      Location:58 → 167
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:219 → 463
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120350593..120362497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154242.1 → XP_036010135.1  potassium voltage-gated channel subfamily G member 4 isoform X3

      Conserved Domains (1) summary
      cl38908
      Location:58 → 167
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_006531289.5 → XP_006531352.1  potassium voltage-gated channel subfamily G member 4 isoform X1

      See identical proteins and their annotated locations for XP_006531352.1

      UniProtKB/Swiss-Prot
      Q80XM3
      Conserved Domains (2) summary
      cl38908
      Location:58 → 167
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:219 → 463
      Ion_trans; Ion transport protein

    3. XM_036154241.1 → XP_036010134.1  potassium voltage-gated channel subfamily G member 4 isoform X2

      Conserved Domains (1) summary
      cl38908
      Location:58 → 167
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XM3.1 GenPept UniProtKB/Swiss-Prot:Q80XM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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