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    Frmpd1 FERM and PDZ domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 666060, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Frmpd1provided by MGI
    Official Full Name
    FERM and PDZ domain containing 1provided by MGI
    Primary source
    MGI:MGI:2446274
    See related
    Ensembl:ENSMUSG00000035615 AllianceGenome:MGI:2446274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0967
    Summary
    Predicted to be involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cytoskeleton; cytosol; and glutamatergic synapse. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell cortex. Orthologous to human FRMPD1 (FERM and PDZ domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 1.8), frontal lobe adult (RPKM 1.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Frmpd1 in Genome Data Viewer
    Location:
    4 B1; 4 23.77 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45183958..45285936)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45184420..45285936)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene F-box protein 10 Neighboring gene predicted gene, 30939 Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45309913-45310096 Neighboring gene tRNA methyltransferase 10B Neighboring gene exosome component 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted deletion of an NRL- and CRX-regulated alternative promoter specifically silences FERM and PDZ domain containing 1 (Frmpd1) in rod photoreceptors. Campla CK, et al. Hum Mol Genet, 2019 Mar 1. PMID 30445545, Free PMC Article
    2. Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina. Campla CK, et al. eNeuro, 2022 Sep-Oct. PMID 36180221, Free PMC Article
    3. 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction. Lu Y, et al. Proc Natl Acad Sci U S A, 2023 Feb 21. PMID 36787362, Free PMC Article
    4. Structural and biochemical characterization of the interaction between LGN and Frmpd1. Pan Z, et al. J Mol Biol, 2013 Mar 25. PMID 23318951
    5. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina.
      Title: Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FERM and PDZ domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081172.3 → NP_001074641.1  FERM and PDZ domain-containing protein 1

      See identical proteins and their annotated locations for NP_001074641.1

      Status: VALIDATED

      Source sequence(s)
      AL772285, AL824706
      Consensus CDS
      CCDS38753.1
      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0
      UniProtKB/TrEMBL
      B2RY18
      Related
      ENSMUSP00000047232.6, ENSMUST00000044773.12
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 500
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd21942
      Location:901 → 938
      LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
      cl28922
      Location:179 → 268
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001425126.1 → NP_001412055.1  FERM and PDZ domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AL772285, AL772322
      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0
      Related
      ENSMUSP00000103434.2, ENSMUST00000107804.2

    3. NM_001425127.1 → NP_001412056.1  FERM and PDZ domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AL772285, AL824706
      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45183958..45285936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538176.5 → XP_006538239.1  FERM and PDZ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006538239.1

      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0
      UniProtKB/TrEMBL
      B2RY18
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 500
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd21942
      Location:901 → 938
      LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
      cl28922
      Location:179 → 268
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006538178.4 → XP_006538241.1  FERM and PDZ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006538241.1

      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0
      UniProtKB/TrEMBL
      B2RY18
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 500
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd21942
      Location:901 → 938
      LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
      cl28922
      Location:179 → 268
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_006538175.4 → XP_006538238.1  FERM and PDZ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006538238.1

      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0
      UniProtKB/TrEMBL
      B2RY18
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 500
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd21942
      Location:901 → 938
      LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
      cl28922
      Location:179 → 268
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_011250085.4 → XP_011248387.1  FERM and PDZ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011248387.1

      UniProtKB/Swiss-Prot
      A2AKB4, Q80TN2, Q80XK5, Q8K0C0
      UniProtKB/TrEMBL
      B2RY18
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 500
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd21942
      Location:901 → 938
      LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
      cl28922
      Location:179 → 268
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AKB4.1 GenPept UniProtKB/Swiss-Prot:A2AKB4

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