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    Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein [ Mus musculus (house mouse) ]

    Gene ID: 66052, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sdhcprovided by MGI
    Official Full Name
    succinate dehydrogenase complex, subunit C, integral membrane proteinprovided by MGI
    Primary source
    MGI:MGI:1913302
    See related
    Ensembl:ENSMUSG00000058076 AllianceGenome:MGI:1913302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610010E03Rik
    Summary
    Predicted to enable heme binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 368.5), kidney adult (RPKM 283.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sdhc in Genome Data Viewer
    Location:
    1 H3; 1 78.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170956726..170978209, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171129157..171150640, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2017 Neighboring gene nuclear encoded tRNA valine 6 (anticodon CAC) Neighboring gene STARR-positive B cell enhancer ABC_E222 Neighboring gene cilia and flagella associated protein 126 Neighboring gene STARR-seq mESC enhancer starr_03017 Neighboring gene predicted gene, 46172 Neighboring gene STARR-positive B cell enhancer ABC_E2018 Neighboring gene myelin protein zero Neighboring gene Purkinje cell protein 4-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
      Title: SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability in an Animal Model of Pulmonary Emphysema.
    2. Studies indicate that the Tet-mev-1 conditional transgenic system can induce mutated SDHC gene in complex II.
      Title: Model animals for the study of oxidative stress from complex II.
    3. a sensor for apoptosis induction
      Title: The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction.
    4. complex II plays an essential role in hypoxic reactive oxygen species production.
      Title: Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103103

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex II (succinate dehydrogenase) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex II (succinate dehydrogenase) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex II (succinate dehydrogenase) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase cytochrome b560 subunit, mitochondrial
    Names
    QPs-1
    QPs1
    integral membrane protein CII-3
    malate dehydrogenase [quinone] cytochrome b560 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025321.3 → NP_079597.2  succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079597.2

      Status: VALIDATED

      Source sequence(s)
      AK002459, AV356234, BY711932
      Consensus CDS
      CCDS35772.1
      UniProtKB/Swiss-Prot
      Q544Q9, Q99JP2, Q9CZB0, Q9DCU7
      UniProtKB/TrEMBL
      Q5XK33
      Related
      ENSMUSP00000106968.4, ENSMUST00000111336.10
      Conserved Domains (1) summary
      cd03499
      Location:50 → 152
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170956726..170978209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496955.3 → XP_006497018.2  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q5XK33
      Conserved Domains (1) summary
      cd03499
      Location:31 → 133
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...

    2. XM_030241961.1 → XP_030097821.1  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2

      UniProtKB/TrEMBL
      F8WGB3
      Conserved Domains (1) summary
      cd03499
      Location:13 → 115
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZB0.1 GenPept UniProtKB/Swiss-Prot:Q9CZB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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