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    Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 [ Mus musculus (house mouse) ]

    Gene ID: 66046, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Ndufb5provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B5provided by MGI
    Primary source
    MGI:MGI:1913296
    See related
    Ensembl:ENSMUSG00000027673 AllianceGenome:MGI:1913296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGDH; CI-SGDH; 0610007D05Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in pancreas epithelium. Orthologous to human NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 156.3), adrenal adult (RPKM 105.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufb5 in Genome Data Viewer
    Location:
    3 A3; 3 15.85 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32791206..32805708)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32737057..32751559)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E179 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:32635708-32635977 Neighboring gene actin-like 6A Neighboring gene STARR-seq mESC enhancer starr_07351 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene ubiquitin specific peptidase 13 (isopeptidase T-3) Neighboring gene peroxisomal biogenesis factor 5-like Neighboring gene predicted gene, 23214

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer. Wang T, et al. J Transl Med, 2024 Jul 9. PMID 38982516, Free PMC Article
    2. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article
    3. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Papanicolaou KN, et al. Circ Res, 2012 Sep 28. PMID 22904094, Free PMC Article
    4. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
    5. Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Li C, et al. Adv Sci (Weinh), 2024 Mar. PMID 38196272, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer.
      Title: METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5
    NADH-ubiquinone oxidoreductase SGDH subunit
    complex I-SGDH
    NP_079592.2
    XP_006535577.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025316.2 → NP_079592.2  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079592.2

      Status: VALIDATED

      Source sequence(s)
      AK004372
      Consensus CDS
      CCDS17300.1
      UniProtKB/Swiss-Prot
      Q9CQH3
      UniProtKB/TrEMBL
      Q8BU20
      Related
      ENSMUSP00000114963.2, ENSMUST00000127477.8
      Conserved Domains (1) summary
      pfam09781
      Location:1 → 188
      NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      32791206..32805708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535514.3 → XP_006535577.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006535577.1

      UniProtKB/TrEMBL
      D3Z568
      Related
      ENSMUSP00000113602.2, ENSMUST00000122290.2
      Conserved Domains (1) summary
      pfam09781
      Location:1 → 118
      NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQH3.1 GenPept UniProtKB/Swiss-Prot:Q9CQH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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