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    Tmem254 transmembrane protein 254 [ Mus musculus (house mouse) ]

    Gene ID: 66039, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem254provided by MGI
    Official Full Name
    transmembrane protein 254provided by MGI
    Primary source
    MGI:MGI:1196450
    See related
    Ensembl:ENSMUSG00000072676 AllianceGenome:MGI:1196450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm9746; Gm10395; Tmem254a; Tmem254b; Tmem254c; D14Ertd449e; 0610008K04Rik; 0610010A22Rik
    Summary
    Predicted to be located in membrane. Is expressed in several structures, including alimentary system; choroid plexus; floor plate; respiratory system; and urinary system. Orthologous to human TMEM254 (transmembrane protein 254). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 50.8), kidney adult (RPKM 46.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem254 in Genome Data Viewer
    Location:
    14 A3; 14 15.49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (25923722..25928096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (25923298..25927672, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene annexin A11 Neighboring gene placenta specific 9 Neighboring gene predicted gene, 57811 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene cytoplasmic polyadenylated homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 254
    Names
    tranmembrane protein 254a
    transmembrane protein 254a
    transmembrane protein 254b
    transmembrane protein 254c
    transmembrane protein C10orf57 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025311.3 → NP_079587.1  transmembrane protein 254 isoform 2

      See identical proteins and their annotated locations for NP_079587.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC165285, AK008299, AV172143, BY270140
      Consensus CDS
      CCDS26876.1
      UniProtKB/Swiss-Prot
      P0DN89
      Related
      ENSMUSP00000098374.5, ENSMUST00000100811.6
      Conserved Domains (1) summary
      pfam14934
      Location:32 → 118
      DUF4499; Domain of unknown function (DUF4499)

    2. NM_026679.2 → NP_080955.1  transmembrane protein 254 isoform 1

      See identical proteins and their annotated locations for NP_080955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC165285, AK002441, AV172143, BY784109
      Consensus CDS
      CCDS49420.1
      UniProtKB/Swiss-Prot
      F6V0T5, P0DN89, P0DN90, P0DN91, Q9D890, Q9DCV5
      Related
      ENSMUSP00000139270.2, ENSMUST00000185006.9
      Conserved Domains (1) summary
      pfam14934
      Location:26 → 112
      DUF4499; Domain of unknown function (DUF4499)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      25923722..25928096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247920.2 → XP_030103780.1  transmembrane protein 254 isoform X1

      Conserved Domains (1) summary
      pfam14934
      Location:32 → 90
      DUF4499; Domain of unknown function (DUF4499)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001270495.1: Suppressed sequence

      Description
      NM_001270495.1: This RefSeq was removed because it is redundant with NM_026679.2.

    2. NM_001270496.1: Suppressed sequence

      Description
      NM_001270496.1: This RefSeq was removed because it is redundant with NM_025311.3.

    3. NM_001270498.1: Suppressed sequence

      Description
      NM_001270498.1: This RefSeq was removed because it is redundant with NM_026679.2.

    4. NM_001270499.1: Suppressed sequence

      Description
      NM_001270499.1: This RefSeq was removed because it is redundant with NM_025311.3.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DN89.1 GenPept UniProtKB/Swiss-Prot:P0DN89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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