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    Rnf130 ring finger protein 130 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 652955, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rnf130provided by RGD
    Official Full Name
    ring finger protein 130provided by RGD
    Primary source
    RGD:1562041
    See related
    EnsemblRapid:ENSRNOG00000046330 AllianceGenome:RGD:1562041
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in programmed cell death and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 384.9), Kidney (RPKM 325.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf130 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (34843920..34957130)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34342835..34456048)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35537976..35610711)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 9 Neighboring gene uncharacterized LOC120095089 Neighboring gene RasGEF domain family, member 1C Neighboring gene microRNA 340-1 Neighboring gene TBC1 domain family member 9B Neighboring gene uncharacterized LOC120095090 Neighboring gene MRN complex interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat leydig cells. Guais A, et al. Biol Reprod, 2004 Jan. PMID 13679316
    2. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. Baker SJ, et al. Gene, 2000 May 2. PMID 10806348
    3. h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. Guais A, et al. Gene, 2006 Jun 7. PMID 16549277
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF130
    Names
    R-goliath
    goliath homolog
    NP_001032747.1
    XP_038942740.1
    XP_038942741.1
    XP_038942742.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037658.2 → NP_001032747.1  E3 ubiquitin-protein ligase RNF130 precursor

      See identical proteins and their annotated locations for NP_001032747.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6Y290
      UniProtKB/TrEMBL
      B2GVA8
      Related
      ENSRNOP00000099640.1, ENSRNOT00000123844.1
      Conserved Domains (2) summary
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:262 → 305
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      34843920..34957130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086813.1 → XP_038942741.1  E3 ubiquitin-protein ligase RNF130 isoform X2

      UniProtKB/TrEMBL
      A0A8I5XWR0
      Related
      ENSRNOP00000107484.1, ENSRNOT00000141833.1
      Conserved Domains (3) summary
      COG5243
      Location:197 → 414
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16803
      Location:262 → 310
      RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

    2. XM_039086814.2 → XP_038942742.1  E3 ubiquitin-protein ligase RNF130 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ATJ8, M0R971
      Related
      ENSRNOP00000066033.3, ENSRNOT00000071917.4
      Conserved Domains (3) summary
      COG5243
      Location:197 → 366
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16803
      Location:262 → 310
      RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

    3. XM_039086812.2 → XP_038942740.1  E3 ubiquitin-protein ligase RNF130 isoform X1

      Conserved Domains (3) summary
      COG5243
      Location:197 → 366
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16803
      Location:262 → 310
      RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Y290.1 GenPept UniProtKB/Swiss-Prot:Q6Y290

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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