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    Ppp1r10 protein phosphatase 1, regulatory subunit 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65045, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ppp1r10provided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 10provided by RGD
    Primary source
    RGD:620079
    See related
    EnsemblRapid:ENSRNOG00000059268 AllianceGenome:RGD:620079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fb19; Pnuts
    Summary
    Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in chromatin. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 132.2), Kidney (RPKM 102.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r10 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (2827802..2842418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2822995..2838125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3329677..3344286, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene proline rich 3 Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene similar to human chromosome 6 open reading frame 136

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. Allen PB, et al. J Biol Chem, 1998 Feb 13. PMID 9461602
    2. PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. Kim YM, et al. J Biol Chem, 2003 Apr 18. PMID 12574161
    3. MicroRNA-34a regulates cardiac ageing and function. Boon RA, et al. Nature, 2013 Mar 7. PMID 23426265
    4. Identification and characterization of a novel human PP1 phosphatase complex. Lee JH, et al. J Biol Chem, 2010 Aug 6. PMID 20516061, Free PMC Article
    5. A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Grolimund L, et al. Nat Commun, 2013. PMID 24270157

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus
      Title: PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PTW/PP1 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 1 regulatory subunit 10
    Names
    MHC class I region proline-rich protein CAT53
    phosphatase 1 nuclear targeting subunit
    putative protein phosphatase 1 nuclear targeting subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022951.2 → NP_075240.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

      See identical proteins and their annotated locations for NP_075240.1

      Status: VALIDATED

      Source sequence(s)
      BC134805, BP477033, BX883048
      UniProtKB/Swiss-Prot
      O55000, Q6MG09
      UniProtKB/TrEMBL
      A0A0G2K3G9, A4QN30
      Related
      ENSRNOP00000098194.1, ENSRNOT00000120552.2
      Conserved Domains (2) summary
      pfam18044
      Location:842 → 864
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      2827802..2842418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099055.2 → XP_038954983.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

      UniProtKB/Swiss-Prot
      O55000, Q6MG09
      UniProtKB/TrEMBL
      A0A0G2K3G9, A4QN30
      Conserved Domains (2) summary
      pfam18044
      Location:842 → 864
      zf-CCCH_4; CCCH-type zinc finger
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55000.1 GenPept UniProtKB/Swiss-Prot:O55000

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials