Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnaja1provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member A1provided by RGD
Primary source: RGD:620942
See related: EnsemblRapid:ENSRNOG00000007029 AllianceGenome:RGD:620942
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsj2
Summary: Enables ATPase activator activity. Predicted to be involved in several processes, including negative regulation of protein modification process; regulation of apoptotic process; and regulation of establishment of protein localization. Predicted to act upstream of or within androgen receptor signaling pathway; flagellated sperm motility; and spermatogenesis. Predicted to be located in membrane and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 696.9), Kidney (RPKM 559.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (60638404..60649315)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (55842414..55853326)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (57028467..57039378)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study uncover a completely new role for the Hdj2 co-chaperone in tumorigenicity
Title: Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135166 (e-PCR)
- UniSTS:218443

PMC153017P1 (e-PCR)
- UniSTS:271247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables C3HC4-type RING finger domain binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dnaJ homolog subfamily A member 1

Names: DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ-like protein 2; HSJ-2; dnaJ-like protein 1; heat shock protein J2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.