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    Mbl2 mannose binding lectin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64668, updated on 2-Nov-2024

    Summary

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    Symbol
    Mbl2provided by RGD
    Full Name
    mannose binding lectin 2provided by RGD
    Primary source
    RGD:67380
    See related
    EnsemblRapid:ENSRNOG00000011637 AllianceGenome:RGD:67380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-001; Ab2-011
    Summary
    Enables several functions, including identical protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in positive regulation of complement activation and positive regulation of protein processing. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1618.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mbl2 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (237429873..237465567)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (228016439..228024736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248435069..248442669)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4, pseudogene 1 Neighboring gene cytochrome c, somatic, pseudogene 1 Neighboring gene ribosomal protein L7a, pseudogene 25 Neighboring gene uncharacterized LOC134484920

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. Crosdale DJ, et al. J Infect Dis, 2001 Sep 1. PMID 11474427
    2. Complement defects in patients with chronic rhinosinusitis. Gaunsbaek MQ, et al. PLoS One, 2012. PMID 23144819, Free PMC Article
    3. A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco. Hamdi S, et al. Infect Genet Evol, 2013 Jan. PMID 22995279
    4. Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors. Gregersen S, et al. Ann Allergy Asthma Immunol, 2010 Jun. PMID 20568383
    5. Epidemiology of chronic wound patients and relation to serum levels of mannan-binding lectin. Bitsch M, et al. Acta Derm Venereol, 2009 Nov. PMID 19997692

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-mannose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-mannose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within complement activation, lectin pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, lectin pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of complement activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of opsonization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in surfactant homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of serine-type endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mannose-binding protein C
    Names
    MBP-C
    RA-reactive factor P28A subunit
    RARF/P28A
    mannan-binding protein
    mannose binding lectin 2 (protein C)
    mannose-binding lectin (protein C) 2
    mannose-binding protein C (liver)
    mannose-binding protein C-like
    ra-reactive factor polysaccharide-binding component p28A
    raRF p28A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022704.2 → NP_073195.2  mannose-binding protein C precursor

      See identical proteins and their annotated locations for NP_073195.2

      Status: PROVISIONAL

      Source sequence(s)
      X05023
      UniProtKB/Swiss-Prot
      P08661
      UniProtKB/TrEMBL
      A6I0Y6
      Conserved Domains (2) summary
      cd03591
      Location:132 → 242
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:36 → 95
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      237429873..237465567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231249.4 → XP_006231311.1  mannose-binding protein C isoform X1

      See identical proteins and their annotated locations for XP_006231311.1

      UniProtKB/Swiss-Prot
      P08661
      UniProtKB/TrEMBL
      A6I0Y6
      Related
      ENSRNOP00000047103.7, ENSRNOT00000050984.7
      Conserved Domains (2) summary
      cd03591
      Location:132 → 242
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:36 → 95
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_063272804.1 → XP_063128874.1  mannose-binding protein C isoform X2

    3. XM_006231250.4 → XP_006231312.1  mannose-binding protein C isoform X1

      See identical proteins and their annotated locations for XP_006231312.1

      UniProtKB/Swiss-Prot
      P08661
      UniProtKB/TrEMBL
      A6I0Y6
      Conserved Domains (2) summary
      cd03591
      Location:132 → 242
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:36 → 95
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08661.2 GenPept UniProtKB/Swiss-Prot:P08661

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