Hpse heparanase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hpseprovided by RGD
Full Name: heparanaseprovided by RGD
Primary source: RGD:61969
See related: EnsemblRapid:ENSRNOG00000002188 AllianceGenome:RGD:61969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hep; Hpa
Summary: Enables heparanase activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan catabolic process; positive regulation of osteoblast proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in lysosome; membrane raft; and nucleoplasm. Predicted to be part of heparanase complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human HPSE (heparanase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 207.9), Spleen (RPKM 114.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (9200971..9241377)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (8896593..8937011)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (10534358..10576686)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identified Hpse as a previously unexplored candidate, being up-regulated following injury. We confirmed these results and demonstrated inhibition of Hpse led to an acceleration of axonal degeneration, accompanied by an increase in b-catenin
Title: Heparanase attenuates axon degeneration following sciatic nerve transection.
Heparanase plays an important role in mediating the neuroinflammatory response after subarachnoid hemorrhage.
Title: Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
Endothelial cell-to-cardiomyocyte transfer of heparanase to modulates the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy.
Title: High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature.
the expression of the gene for heparanase was increased in the right and left ventricles after treatment with monocrotaline
Title: Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats.
Inhibiting heparanase function could offer a new strategy for managing cardiomyopathy observed after diabetes.
Title: Endothelial cell heparanase taken up by cardiomyocytes regulates lipoprotein lipase transfer to the coronary lumen after diabetes.
Suggest that the heparanase-lipoprotein lipase-VEGF axis amplifies fatty acid delivery, a rapid and adaptive mechanism that is geared to overcome the loss of glucose consumption by the diabetic heart.
Title: Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase.
active heparanase released lipoprotein lipase from the myocyte surface
Title: Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes.
Heparanase and TFPI are locally elevated in the process of avascular necrosis and are normalized on treatment.
Title: Heparanase role in the treatment of avascular necrosis of femur head.
Heparanase gene is involved in heparan sulfate proteoglycans metabolism.
Title: Expression of Ext1, Ext2, and heparanase genes in brain of senescence-accelerated OXYS rats in early ontogenesis and during development of neurodegenerative changes.
HPR1 production is increased in endothelial cells from rat models of diabetes, and in macrophages in atherosclerotic lesions of diabetic and nondiabetic patients. Increased HPR1 production may contribute to pathogenesis and progression of atherosclerosis.
Title: Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Markers

RH141764 (e-PCR)
- UniSTS:223757

D21S1270 (e-PCR), detects polymorphism
- UniSTS:31268

RH141824 (e-PCR)
- UniSTS:223816

BE115323 (e-PCR)
- UniSTS:248139

AA690179 (e-PCR)
- UniSTS:207837

RH128886 (e-PCR)
- UniSTS:212194

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparanase activity	IDA Inferred from Direct Assay more info	PubMed
enables heparanase activity	IEA Inferred from Electronic Annotation more info
contributes_to heparanase activity	ISO Inferred from Sequence Orthology more info
enables heparanase activity	ISO Inferred from Sequence Orthology more info
enables syndecan binding	IEA Inferred from Electronic Annotation more info
enables syndecan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis involved in wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heparin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in heparin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair follicle development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
involved_in vascular wound healing	IEA Inferred from Electronic Annotation more info
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of heparanase complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heparanase

Names: endo-glucoronidase

NP_072127.1

EC 3.2.1.166

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.