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    Mlst8 MTOR associated protein, LST8 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64226, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Mlst8provided by RGD
    Official Full Name
    MTOR associated protein, LST8 homologprovided by RGD
    Primary source
    RGD:69242
    See related
    EnsemblRapid:ENSRNOG00000009667 AllianceGenome:RGD:69242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gbl
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within positive regulation of actin filament polymerization; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of GTPase activity. Located in cytosol. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 67.5), Adrenal (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mlst8 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14002927..14008678, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13498377..13504128, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13839250..13845001, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene E4F transcription factor 1 Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene CASK interacting protein 1 Neighboring gene TNF receptor associated factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insulin regulation of a novel WD-40 repeat protein in adipocytes. Rodgers BD, et al. J Endocrinol, 2001 Feb. PMID 11182770
    2. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Kato H, et al. Cell Death Differ, 2012 Feb. PMID 21779001, Free PMC Article
    3. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Kim DH, et al. Mol Cell, 2003 Apr. PMID 12718876
    4. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. Kamano Y, et al. FEBS Lett, 2013 Oct 11. PMID 24036451
    5. Molecular mechanisms of mTOR-mediated translational control. Ma XM, et al. Nat Rev Mol Cell Biol, 2009 May. PMID 19339977

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114322

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    target of rapamycin complex subunit LST8
    Names
    G beta-like protein
    TORC subunit LST8
    mammalian lethal with SEC13 protein 8
    protein GbetaL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022404.2 → NP_071799.2  target of rapamycin complex subunit LST8

      See identical proteins and their annotated locations for NP_071799.2

      Status: VALIDATED

      Source sequence(s)
      BC097319, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4QRA0, Q9Z2K5
      UniProtKB/TrEMBL
      A0A8I5ZL90, A6HCT2
      Related
      ENSRNOP00000078598.1, ENSRNOT00000101517.2
      Conserved Domains (2) summary
      cd00200
      Location:14 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:47 → 83
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14002927..14008678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597522.3 → XP_017453011.1  target of rapamycin complex subunit LST8 isoform X1

      UniProtKB/Swiss-Prot
      Q4QRA0, Q9Z2K5
      UniProtKB/TrEMBL
      A0A8I5ZL90, A6HCT2
      Conserved Domains (2) summary
      cd00200
      Location:14 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:47 → 83
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2K5.2 GenPept UniProtKB/Swiss-Prot:Q9Z2K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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