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    TINAGL1 tubulointerstitial nephritis antigen like 1 [ Homo sapiens (human) ]

    Gene ID: 64129, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TINAGL1provided by HGNC
    Official Full Name
    tubulointerstitial nephritis antigen like 1provided by HGNC
    Primary source
    HGNC:HGNC:19168
    See related
    Ensembl:ENSG00000142910 MIM:616064; AllianceGenome:HGNC:19168
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARG1; LCN7; LIECG3; TINAGRP
    Summary
    The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in placenta (RPKM 120.0), fat (RPKM 61.8) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TINAGL1 in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31576515..31587686)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31434200..31445387)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32042116..32053287)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 645 Neighboring gene uncharacterized LOC124903917 Neighboring gene Sharpr-MPRA regulatory region 14090 Neighboring gene uncharacterized LOC105378626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32034359-32034860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32041927-32042647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 571 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:32070860-32072059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32080194-32080980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32083206-32083895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090464-32090964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090965-32091465 Neighboring gene hypocretin receptor 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32110207-32110977 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:32123622-32123860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32124291-32124792 Neighboring gene collagen type XVI alpha 1 chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1. Lee D, et al. J Transl Med, 2024 Feb 14. PMID 38355577, Free PMC Article
    2. Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein. Brömme NC, et al. Biochem Biophys Res Commun, 2000 May 10. PMID 10799322
    3. YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation. Zhang L, et al. Cell Signal, 2024 Oct. PMID 39098703
    4. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. Wex T, et al. Biochemistry, 2001 Feb 6. PMID 11170462
    5. TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer. Umeyama H, et al. BMC Genomics, 2014. PMID 25521548, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation.
      Title: YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation.
    2. Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin beta1.
      Title: Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1.
    3. Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
      Title: Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
    4. Results show that lower TINAGL1 expression correlates with advanced triple-negative breast cancer (TNBC) tumor stages, reduced disease-free survival (DFS) and distant metastasis-free survival. Consistent with higher risk of metastatic relapse in breast tumors with lower expression of TINAGL1, highly metastatic human breast cancer cell lines express lower TINAGL1 levels than weakly metastatic cells.
      Title: Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
    5. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.
      Title: Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α.
    6. TINAGL1 and B3GALNT1 are possible candidates for drug compounds that inhibit their gene expression
      Title: TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulointerstitial nephritis antigen-like
    Names
    OLRG-2
    P3ECSL
    TIN Ag-related protein
    TIN-Ag-RP
    TINAG-like 1
    androgen-regulated gene 1
    glucocorticoid-inducible protein 5
    lipocalin 7
    oxidized-LDL responsive gene 2
    tubulointerstitial nephritis antigen-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028164.1 RefSeqGene

      Range
      5031..16202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204414.2 → NP_001191343.1  tubulointerstitial nephritis antigen-like isoform 2 precursor

      See identical proteins and their annotated locations for NP_001191343.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF205436, AK298382
      Consensus CDS
      CCDS55586.1
      UniProtKB/TrEMBL
      B4DVG5
      Related
      ENSP00000395137.2, ENST00000457433.6
      Conserved Domains (2) summary
      cd02620
      Location:173 → 424
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam01033
      Location:54 → 94
      Somatomedin_B; Somatomedin B domain

    2. NM_001204415.2 → NP_001191344.1  tubulointerstitial nephritis antigen-like isoform 3

      See identical proteins and their annotated locations for NP_001191344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AF205436, AK298382, BM923842
      Consensus CDS
      CCDS72745.1
      UniProtKB/TrEMBL
      F6SDV2
      Related
      ENSP00000445392.2, ENST00000537531.2
      Conserved Domains (2) summary
      cd02620
      Location:99 → 350
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam05375
      Location:12 → 36
      Pacifastin_I; Pacifastin inhibitor (LCMII)

    3. NM_022164.3 → NP_071447.1  tubulointerstitial nephritis antigen-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_071447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC064633, DA656570
      Consensus CDS
      CCDS343.1
      UniProtKB/Swiss-Prot
      A8K9Q5, B4DPK6, D3DPN8, Q8TEJ9, Q8WZ23, Q96GZ4, Q96JW3, Q9GZM7
      UniProtKB/TrEMBL
      B4DVG5
      Related
      ENSP00000271064.7, ENST00000271064.12
      Conserved Domains (3) summary
      cd02620
      Location:204 → 455
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      cl17735
      Location:105 → 140
      VWC; von Willebrand factor type C domain
      cl02508
      Location:54 → 94
      Somatomedin_B; Somatomedin B domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      31576515..31587686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271106.4 → XP_005271163.1  tubulointerstitial nephritis antigen-like isoform X1

      UniProtKB/TrEMBL
      B4DVG5
      Conserved Domains (1) summary
      cl23744
      Location:204 → 364
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...

    2. XM_005271107.2 → XP_005271164.1  tubulointerstitial nephritis antigen-like isoform X3

      See identical proteins and their annotated locations for XP_005271164.1

      UniProtKB/TrEMBL
      F6SDV2
      Conserved Domains (2) summary
      cd02620
      Location:99 → 350
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam05375
      Location:12 → 36
      Pacifastin_I; Pacifastin inhibitor (LCMII)

    3. XM_047427608.1 → XP_047283564.1  tubulointerstitial nephritis antigen-like isoform X4

    4. XM_011541946.2 → XP_011540248.2  tubulointerstitial nephritis antigen-like isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      31434200..31445387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338153.1 → XP_054194128.1  tubulointerstitial nephritis antigen-like isoform X1

    2. XM_054338155.1 → XP_054194130.1  tubulointerstitial nephritis antigen-like isoform X3

      UniProtKB/TrEMBL
      F6SDV2

    3. XM_054338156.1 → XP_054194131.1  tubulointerstitial nephritis antigen-like isoform X4

    4. XM_054338154.1 → XP_054194129.1  tubulointerstitial nephritis antigen-like isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZM7.1 GenPept UniProtKB/Swiss-Prot:Q9GZM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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