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    Smoc2 SPARC related modular calcium binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 64074, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Smoc2provided by MGI
    Official Full Name
    SPARC related modular calcium binding 2provided by MGI
    Primary source
    MGI:MGI:1929881
    See related
    Ensembl:ENSMUSG00000023886 AllianceGenome:MGI:1929881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smoc2l; 1700056C05Rik; 5430426J21Rik
    Summary
    Enables calcium ion binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 125.2), subcutaneous fat pad adult (RPKM 55.4) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smoc2 in Genome Data Viewer
    Location:
    17 A2; 17 8.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (14499768..14625052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (14279490..14404790)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41531 Neighboring gene predicted gene, 34772 Neighboring gene predicted gene, 34567 Neighboring gene predicted gene, 52280 Neighboring gene STARR-seq mESC enhancer starr_41893 Neighboring gene RIKEN cDNA 4930474M22 gene Neighboring gene predicted gene, 38551 Neighboring gene VISTA enhancer mm1999 Neighboring gene predicted gene, 34916 Neighboring gene STARR-seq mESC enhancer starr_41894 Neighboring gene predicted gene, 53989

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2.
      Title: microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2.
    2. Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
      Title: Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
    3. A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
      Title: A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
    4. Liver fibrosis induced by high fat diet was clearly ameliorated by SMOC2 deficiency mainly through inhibiting transforming growth factor (TGF)-beta1 expression.
      Title: Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.
    5. SMOC2 can act as an inhibitor of mineralization; there is a possible role for SMOC2 to prevent calcification disorders.
      Title: SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.
    6. By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells
      Title: mmu-miR-1963 negatively regulates the ameloblast differentiation of LS8 cell line by directly targeting Smoc2 3'UTR.
    7. SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
      Title: Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.
    8. results indicate that Smoc2 is a novel transcriptional target of activated Ahr. Perturbation of Smoc2 expression may mediate the adverse developmental effects of environmental aryl-hydrocarbon exposure
      Title: The developmentally-regulated Smoc2 gene is repressed by Aryl-hydrocarbon receptor (Ahr) signaling.
    9. SMOC-2 contributes to cell cycle progression by maintaining ILK activity during G1.
      Title: The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.
    10. SMOC-2, like other members of the BM40/SPARC family, acts as a regulator of cell-matrix interactions.
      Title: The widely expressed extracellular matrix protein SMOC-2 promotes keratinocyte attachment and migration.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interstitial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SPARC-related modular calcium-binding protein 2
    Names
    SMOC-2
    secreted modular calcium-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022315.2 → NP_071710.2  SPARC-related modular calcium-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_071710.2

      Status: VALIDATED

      Source sequence(s)
      AK030958, BB840063, BY690973
      Consensus CDS
      CCDS37442.1
      UniProtKB/Swiss-Prot
      Q8CD91, Q8VCM1, Q9D9K2, Q9ER95
      UniProtKB/TrEMBL
      Q3TVR8
      Related
      ENSMUSP00000024660.9, ENSMUST00000024660.9
      Conserved Domains (4) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:215 → 281
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:352 → 413
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam16597
      Location:154 → 212
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      14499768..14625052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524777.4 → XP_006524840.1  SPARC-related modular calcium-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A3B2WCK7, Q3TVR8
      Related
      ENSMUSP00000156572.2, ENSMUST00000233344.2
      Conserved Domains (5) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:226 → 292
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd16241
      Location:315 → 428
      EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
      pfam00086
      Location:90 → 153
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:154 → 225
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CD91.1 GenPept UniProtKB/Swiss-Prot:Q8CD91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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