Oxct2a 3-oxoacid CoA transferase 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxct2aprovided by MGI
Official Full Name: 3-oxoacid CoA transferase 2Aprovided by MGI
Primary source: MGI:MGI:1891061
See related: Ensembl:ENSMUSG00000076436 AllianceGenome:MGI:1891061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oxct; Scot; Oxct2; Scot-t1
Summary: Enables succinyl-CoA:3-oxo-acid CoA-transferase activity. Acts upstream of or within cellular ketone body metabolic process. Located in mitochondrion. Is expressed in amygdala and telencephalon mantle layer. Orthologous to human OXCT2 (3-oxoacid CoA-transferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 4 D2.2; 4 57.42 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123215668..123217472, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123321875..123323679, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AMPKalpha2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation.
Title: AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation.
Two tyrosine residues of SCOT are the priority sites attacked by nitric oxide, and their nitration status is a causal factor leading to inhibition of SCOT catalysis.
Title: The nitrated proteome in heart mitochondria of the db/db mouse model: characterization of nitrated tyrosine residues in SCOT.
germ cells and somatic cells differentially express the SCOT enzymes and that the SCOT activity of sperm caused exclusively by SCOT-t should play an important role in sperm activity.
Title: Differential expression of succinyl CoA transferase (SCOT) genes in somatic and germline cells of the mouse testis.
Oxct2a and Oxct2b are testicular haploid germ cell-specific genes
Title: Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in ketone body catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ketone body metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ketone body metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within succinyl-CoA metabolic process	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial

Names: haploid germ cell specific succinyl CoA transferase; succinyl-CoA:3-oxoacid CoA-transferase; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1

NP_071316.1

EC 2.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022033.4 → NP_071316.1 succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor

See identical proteins and their annotated locations for NP_071316.1

Status: VALIDATED

Source sequence(s)

AB022180, BC137887

Consensus CDS

CCDS18617.1

UniProtKB/Swiss-Prot

B9EHG5, Q2HJ06, Q9ESL0, Q9JJN4

Related

ENSMUSP00000099700.2, ENSMUST00000102640.2

Conserved Domains (3) summary

COG1788
Location:49 → 274

AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

COG4670
Location:49 → 515

YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

cl00339
Location:299 → 506

SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...