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    Dusp12 dual specificity phosphatase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64014, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dusp12provided by RGD
    Official Full Name
    dual specificity phosphatase 12provided by RGD
    Primary source
    RGD:68375
    See related
    EnsemblRapid:ENSRNOG00000003100 AllianceGenome:RGD:68375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GKAP
    Summary
    Enables kinase binding activity and phosphoprotein phosphatase activity. Involved in positive regulation of glucokinase activity and protein dephosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 47.3), Adrenal (RPKM 45.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp12 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (85654914..85666431, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83122192..83131800, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89258309..89267402, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1-like Neighboring gene DNA methyltransferase 3B, pseudogene 2 Neighboring gene uncharacterized LOC120096314 Neighboring gene Fc receptor-like B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy. Cheng J, et al. J Biochem Mol Toxicol, 2023 May. PMID 36644958
    2. A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate. Muñoz-Alonso MJ, et al. J Biol Chem, 2000 Oct 20. PMID 10913113
    3. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. Muda M, et al. J Biol Chem, 1999 Aug 20. PMID 10446167
    4. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789
    5. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy.
      Title: DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 12
    Names
    glucokinase-associated dual specificity phosphatase
    NP_071584.1
    XP_038946987.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022248.2 → NP_071584.1  dual specificity protein phosphatase 12

      See identical proteins and their annotated locations for NP_071584.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q9JIM4
      UniProtKB/TrEMBL
      A0A8I6AB94, A6IDQ3
      Related
      ENSRNOP00000004179.2, ENSRNOT00000004179.5
      Conserved Domains (1) summary
      cd00127
      Location:26 → 165
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      85654914..85666431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091059.2 → XP_038946987.1  dual specificity protein phosphatase 12 isoform X1

      UniProtKB/TrEMBL
      A6IDQ4
      Conserved Domains (1) summary
      cd14520
      Location:28 → 172
      DSP_DUSP12; dual specificity phosphatase domain of dual specificity protein phosphatase 12 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIM4.1 GenPept UniProtKB/Swiss-Prot:Q9JIM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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