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    Arhgap17 Rho GTPase activating protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63994, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgap17provided by RGD
    Official Full Name
    Rho GTPase activating protein 17provided by RGD
    Primary source
    RGD:628767
    See related
    EnsemblRapid:ENSRNOG00000013836 AllianceGenome:RGD:628767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rich1
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in cytoplasm. Biomarker of acute myocardial infarction. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 158.2), Spleen (RPKM 154.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap17 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (187238675..187328093, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177807579..177897027, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (193239036..193328425, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483807 Neighboring gene solute carrier family 5 member 11 Neighboring gene leucine carboxyl methyltransferase 1 Neighboring gene uncharacterized LOC134483809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of nadrin variants, a novel family of GTPase activating protein for rho GTPases. Furuta B, et al. J Neurochem, 2002 Sep. PMID 12358749
    2. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada A, et al. J Biol Chem, 2000 Nov 24. PMID 10967100
    3. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, et al. J Proteomics, 2020 Jun 30. PMID 32068187
    4. External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Galic M, et al. Nat Cell Biol, 2012 Aug. PMID 22750946, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93451

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium-ion regulated exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 17
    Names
    neuron-associated developmentally-regulated protein
    neuron-specific GTPase-activating protein
    rho-type GTPase-activating protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270692.1 → NP_001257621.1  rho GTPase-activating protein 17 isoform 1

      See identical proteins and their annotated locations for NP_001257621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB042827, BC085736
      UniProtKB/Swiss-Prot
      Q8R506, Q99N37, Q99N38, Q9EQV7
      UniProtKB/TrEMBL
      F1M6X7
      Related
      ENSRNOP00000038504.7, ENSRNOT00000031770.9
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    2. NM_001270693.1 → NP_001257622.1  rho GTPase-activating protein 17 isoform 3

      See identical proteins and their annotated locations for NP_001257622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon with an in-frame stop codon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB042827, BC085736, JAXUCZ010000001
      UniProtKB/TrEMBL
      D4AAV4
      Related
      ENSRNOP00000019309.8, ENSRNOT00000019309.10
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    3. NM_001270694.1 → NP_001257623.1  rho GTPase-activating protein 17 isoform 4

      See identical proteins and their annotated locations for NP_001257623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains an alternate 3' exon with an in-frame stop codon compared to variant 1. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB042827, BC085736, JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ALM5
      Related
      ENSRNOP00000019305.9, ENSRNOT00000019304.9
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    4. NM_022244.2 → NP_071580.1  rho GTPase-activating protein 17 isoform 2

      See identical proteins and their annotated locations for NP_071580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB042827, BC085736
      UniProtKB/TrEMBL
      A6I8Z6
      Related
      ENSRNOP00000076440.2, ENSRNOT00000097528.2
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      187238675..187328093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089209.2 → XP_038945137.1  rho GTPase-activating protein 17 isoform X1

      UniProtKB/TrEMBL
      F1M6X7
      Related
      ENSRNOP00000080152.2, ENSRNOT00000105291.2
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

    2. XM_039089216.2 → XP_038945144.1  rho GTPase-activating protein 17 isoform X4

      UniProtKB/TrEMBL
      A6I8Z6
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

    3. XM_039089217.2 → XP_038945145.1  rho GTPase-activating protein 17 isoform X6

      Conserved Domains (1) summary
      cd04386
      Location:1 → 173
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

    4. XM_006230194.5 → XP_006230256.2  rho GTPase-activating protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y535, A0A8I5ZP42
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

    5. XM_063272630.1 → XP_063128700.1  rho GTPase-activating protein 17 isoform X2

    6. XM_063272639.1 → XP_063128709.1  rho GTPase-activating protein 17 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N37.1 GenPept UniProtKB/Swiss-Prot:Q99N37

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